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| Study on the Relationship and Clinical Value of Prognostic Regression of Paediatric Severe Pneumonia with MPV/PLT and Inflammatory Response Related Indexes |
| ZHOU Beibei, LI Jie, ZHANG Meng |
| Lu 'an People's Hospital, Anhui Lu 'an 237000, China |
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Abstract Objective: To analyze the correlation of prognosis outcome of children with severe pneumonia (SP), with mean platelet volume (MPV)/platelet count (PLT) and inflammatory response-related indicators, and evaluate its predictive value on prognosis outcome in children with SP. Methods: Totally 115 children with SP in the hospital were selected from July 2022 to July 2024 as the study subjects. According to the prognosis outcome status, the patients were divided into good prognosis group (n=87) and poor prognosis (n=28) group. The levels of MPV/PLT, lactate dehydrogenase (LDH), procalcitonin (PCT) and C-reactive protein (CRP) were measured among all study subjects. Logistic correlation analysis was applied to analyze the association between MPV/PLT, LDH, PCT and CRP levels and prognosis outcome of SP children. The predictive value of MPV/PLT, LDH, PCT and CRP on the prognosis outcomes of SP in children was analyzed by receiver operating characteristic curve (ROC). Results: The MPV/PLT, LDH, PCT and CRP in the poor prognosis group were higher than those in the good prognosis group (P<0.05). Logistic correlation analysis demonstrated that MPV/PLT, LDH, PCT and CRP levels were closely correlated with the prognosis outcome of SP children (P<0.05). ROC curve indicated that the area under the curve (AUC), sensitivity and specificity of MPV/PLT, LDH, PCT and CRP in predicting the prognosis outcome were 0.953, 83.33% and 97.01%. The efficiency of combined prediction was better than that of each indicator alone (P<0.05). Conclusion: The prognosis outcome of SP in children is closely related to MPV/PLT and inflammatory response-related indicators. Early determination of MPV/PLT, LDH, PCT and CRP levels can provide a certain reference for clinical prediction of prognosis outcome of children with SP.
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2025, Vol. 31 
