骶神经调节术辅助治疗对脊髓损伤后神经源性膀胱患者尿流动力学及尿路感染的影响

doi:10.3969/j.issn.1006-6233.2025.04.013

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摘要 目的: 分析骶神经调节术辅助治疗脊髓损伤后神经源性膀胱的效果。方法: 以2021年3月至2024年3月本院收治的112例脊髓损伤后神经源性膀胱患者按照简单随机抽样法分为对照组(n=56,常规治疗)和观察组(n=56,骶神经调节术辅助治疗+常规治疗)。评价两组的尿流动力学指标、排尿功能、尿路感染发生情况及生活质量。结果: 治疗后,相较于对照组,观察组的残余尿量减少,最大膀胱容量、最大尿流率增加(P<0.05);治疗后,相较于对照组,观察组的日均排尿次数、日均尿失禁次数减少,单次排尿量增加(P<0.05);相较于对照组,观察组的尿路感染发生率明显降低(P<0.05);治疗后,相较于对照组,观察组的生活质量综合评定量表(GQOLI-74)各维度评分升高(P<0.05)。结论: 对脊髓损伤后神经源性膀胱患者应用骶神经调节术辅助治疗可改善其尿流动力学参数及排尿功能,减少尿路感染,提高生活质量。

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	白晓静
	马亚芳
	陈萌

关键词 ：脊髓损伤, 神经源性膀胱, 骶神经调节术, 尿流动力学, 排尿功能, 尿路感染, 生活质量

Abstract：Objective: To analyze the effect of sacral neuromodulation adjuvant therapy on neurogenic bladder (NB) after spinal cord injury (SCI). Methods: Totally 112 patients with NB after SCI in the hospital from March 2021 to March 2024 were divided into a control group (n=56, conventional treatment) and a treatment group (n=56, sacral neuromodulation adjuvant therapy + conventional treatment) using simple random sampling method. The urodynamic indexes, urination function, occurrence of urinary tract infection (UTI), and quality of life in the two groups were evaluated. Results: After treatment, the residual urine volume in the treatment group was decreased while the maximum bladder capacity and maximum urinary flow rate were increased compared with those in the control group (P<0.05). After treatment, compared with the control group, the daily average urination frequency and daily average urinary incontinence frequency were reduced while the single urination volume was enhanced in the treatment group (P<0.05). The incidence of UTI declined significantly in the treatment group compared to the control group (P<0.05). The scores of dimensions of General Quality of Life Inventory-74 (GQOLI-74) in the treatment group after treatment were higher than those in the control group (P<0.05). Conclusion: The application of sacral neuromodulation adjuvant therapy can improve the urodynamics and urination function, reduce the UTI, and strengthen the quality of life in patients with NB after SCI.

Key words： Spinal cord injury Neurogenic bladder Sacral neuromodulation Urodynamics Urination function Urinary tract infection Quality of life

基金资助:陕西省重点研发计划项目,(编号:2024SF-YBXM-192)

引用本文:

白晓静, 马亚芳, 陈萌. 骶神经调节术辅助治疗对脊髓损伤后神经源性膀胱患者尿流动力学及尿路感染的影响[J]. 河北医学, 2025, 31(4): 609-613.
BAI Xiaojing, MA Yafang, CHEN Meng. Influence of Sacral Neuromodulation Adjuvant Therapy on Urodynamics and Urinary Tract Infection in Patients with Neurogenic Bladder after Spinal Cord Injury. HeBei Med, 2025, 31(4): 609-613.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.04.013 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I4/609