母婴ABO血型不合引起新生儿溶血病血清学检验结果与孕妇免疫球蛋白G抗体效价的关联性分析

doi:10.3969/j.issn.1006-6233.2025.05.021

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摘要 目的: 分析母婴ABO血型不合引起新生儿溶血病(HDN)血清学检验结果与孕妇免疫球蛋白G(IgG)抗体效价的关联性。方法: 选取2021年5月至2024年5月在本院接受诊断的142例HDN患儿为研究对象,HDN患儿均由ABO血型抗原不合所引起,均接受血型和相关血清学检测。结果: 在ABO血型抗原不合所引起的142例HDN患儿中,A、B患儿占比分别为55.63%、44.37%。142例HDN患儿经血清学检测,直接抗人球蛋白试验、游离IgG抗体试验、抗体释放试验检测阳性率分别为12.68%、48.59%、100%。IgG型抗A(B)抗体效价大小为1∶64、1∶128、1∶256、1∶512、1∶1024,HDN例数分别为64例(45.07%)、37例(26.06%)、22例(15.49%)、11例(7.75%)、8例(5.63%)。轻度HDN组、中重度HDN组患儿的IgG抗体效价大小差异有统计学意义(P<0.05)。结论: IgG抗体效价与HDN严重程度具有相关性。

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	马玉
	杨劲
	孙仁俊

关键词 ：母婴ABO血型不合, 新生儿溶血病, 血清学检验, 孕妇免疫球蛋白G抗体效价

Abstract：Objective: To analyze the correlation between serologic testing results and maternal immunoglobulin G (IgG) antibody titer in hemolytic disease of newborn (HDN) induced by ABO blood group incompatibility. Methods: A total of 142 children with HDN induced by ABO blood group antigen incompatibility in the hospital were enrolled as the research objects between May 2021 and May 2024. All children underwent blood group and related serology examinations. Results: In the 142 children with HDN induced by ABO blood group antigen incompatibility, positive rates in children with groups A and B were 55.63% and 44.37%, respectively. According to serologic testing, positive rates of direct anti-human globulin test, free IgG antibody test and antibody release test were 12.68%, 48.59% and 100%, respectively. The titer distribution of IgG anti-A (B) antibody was as follows: 1∶64, 1∶128, 1∶256, 1∶592, 1∶1024, and the corresponding number of cases was as follows: 64 cases(45.07%), 37 cases(26.06%), 22 cases(15.49%), 11 cases(7.75%), 8 cases(5.63%). There were significant differences in titer distribution of IgG antibody between mild HDN group and moderate to severe HDN group (P<0.05). Conclusion: The titer of IgG antibody is correlated with the severity of HDN.

Key words： ABO blood group incompatibility Hemolytic disease of newborn Serologic test Maternal immunoglobulin G antibody titer

基金资助:2020年度安徽省自然科学基金项目,(编号:2008085QB73)

引用本文:

马玉, 杨劲, 孙仁俊. 母婴ABO血型不合引起新生儿溶血病血清学检验结果与孕妇免疫球蛋白G抗体效价的关联性分析[J]. 河北医学, 2025, 31(5): 824-826.
MA Yu, YANG Jin, SUN Renjun. Correlation between Serologic Testing Results and Maternal Immunoglobulin G antibody Titer in Hemolytic Disease of Newborn Induced by ABO Blood Group Incompatibility. HeBei Med, 2025, 31(5): 824-826.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.05.021 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I5/824

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