Abstract：Objective: To explore the relationship between changes of amplitude-integrated electroencephalogram (aEEG) and brain development in premature infants at different gestational ages. Methods: A total of 103 premature infants admitted to the hospital from January 2023 to April 2024 were selected as the research subjects. They were grouped according to gestational age. The changes of aEEG were analyzed. All subjects underwent multimodal magnetic resonance imaging (MRI) examination, and diffusion tensor imaging (DTI) was used to quantitatively evaluate their brain development. Spearman method was used to analyze the relationship between aEEG changes and brain development in premature infants at different gestational ages. Results: As gestational age increased, the positive rate of continuity (Co) increased. There were statistically significant differences in Co positive rate of aEEG among premature infants of different gestational ages (P<0.05). As gestational age increased, the positive rate of sleep-wakefulness cycle (SWC) increased. There were statistically significant differences in SWC positive rate of aEEG among premature infants of different gestational ages (P<0.05). As gestational age increased, lower-bound (LB) amplitude increased. There were statistically significant differences in LB of aEEG < 3μV and aEEG >5μV among premature infants of different gestational ages (P<0.05). As the gestational age increased, bandwidth (B) decreased, and there were statistically significant differences in B of aEEG among premature infants of different gestational ages (P<0.05). There were statistically significant differences in fractional anisotropy (FA) values of frontal white matter, parietal white matter, splenium of the corpus callosum, and cerebral peduncle among premature infants at different gestational ages (P<0.05). Spearman correlation analysis results showed that LB was negatively correlated with FA values of the splenium of the corpus callosum and cerebral peduncle. B was positively correlated with FA value of parietal white matter, and negatively correlated with FA value of cerebral peduncle (P<0.05). Conclusion: With the increase of gestational age, aEEG becomes mature, which mainly manifests as increases in Co and SWC positive rates, increase in LB and decrease in B. Closely related to brain development in premature infants.
王雪红, 王娟, 陈丹, 杨莹莹, 王栋梅. 不同胎龄早产儿振幅整合脑电图变化及与脑发育的关系[J]. 河北医学, 2025, 31(6): 954-958.
WANG Xuehong, WANG Juan, CHEN Dan, et al. Amplitude-Integrated Electroencephalographic Changes in Preterm Infants of Different Gestational Ages and Their Relation to Brain Development. HeBei Med, 2025, 31(6): 954-958.
[1] Kloosterboer S,Anolda Naber FB,Heyman H,et al.A Preliminary study of correlates of premature birth and their influence on cortisol levels in young children[J].Biol Res Nurs,2024,26(2):240-247. [2] Muller H,Storbeck T,Katzer D,et al.Neurological outcome at 24 months corrected age of prematurely born infants after preterm premature rupture of membranes (PPROM) of at least 7 days:a two-center experience in Germany[J].Matern Fetal Neonatal Med,2020,33(8):1315-1320. [3] Clarke G,Aatsinki A,O'Mahony SM.Brain development in premature infants:a bug in the programming system[J].Cell Host Microbe,2021,29(10):1477-1479. [4] Shen L,Tao MY,Shi YX,et al.Value of amplitude-integrated electroencephalogram combined with quantitative indices of cranial magnetic resonance imaging in predicting short-term neurodevelopment in moderately and late preterm infants:a prospective study[J].Zhongguo Dang Dai Er Ke Za Zhi,2021,23(10):987-993. [5] Segar J,Jetton JG.Diuretic use,acute kidney injury,and premature infants:the call for evidence-based guidelines[J].Pediatr Nephrol,2021,36(12):3807-3811. [6] Kuint J,Turgeman A,Torjman A,et al.Characteristics of amplitude-integrated electroencephalogram in premature infants[J].Child Neurol,2007,22(3):277-81. [7] Tandircioglu UA,Guzoglu N,Gucuyener K,et al.Influence of intensive care unit enlightenment on premature infants on functional brain maturation assessed by amplitude-integrated electroencephalograph[J].Am Perinatol,2021,38(4):357-362. [8] Cordeiro M,Peinado H,Montes MT,et al.Evaluation of the suitability and clinical applicability of different electrodes for aEEG/cEEG monitoring in the extremely premature infant[J].An Pediatr (Engl Ed),2021,95(6):423-430. [9] Park KH,Kim YM,Lee YJ,et al.Predictive value of an early amplitude-integrated electroencephalogram for short-term neurologic outcomes in preterm infants[J].Turk Pediatr,2020;62(3):367-378. [10] Deshpande P,McNamara PJ,Hahn C,et al.A practical approach toward interpretation of amplitude integrated electroencephalography in preterm infants[J].Eur Pediatr,2022,181(6):2187-2200. [11] Chahine A,Chenouard A,Joram N,et al.Continuous amplitude-integrated electroencephalography during neonatal and pediatric extracorporeal membrane oxygenation[J].Clin Neurophysiol,2023,40(4):317-324. [12] Sharma GK,Natarajan CK,Hementhakumar V,et al.Prognostic value of amplitude-integrated electroencephalography in term neonates with encephalopathy[J].Indian Pediatr,2021,58(10):928-931. [13] De Asis-Cruz J,Andescavage N,Limperopoulos C.Adverse prenatal exposures and fetal brain development:insights from advanced fetal magnetic resonance imaging[J].Biol Psychiatry Cogn Neurosci Neuroimaging,2022,7(5):480-490.
2025, Vol. 31 
冀公网安备13080202000786号