摘要目的:探究纤维蛋白原/白蛋白比值(fibrinogen to albumin ratio,FAR)、血小板参数与冠状动脉病变程度相关性。方法:回顾性分析2021年1月至2024年8月期间在本院行冠脉造影检查的154例患者的临床资料,依据冠脉造影结果分冠心病(CHD)组(n=108)和对照组(n=46),依据Gensini积分系统评估结果将CHD组分为轻中度病变组(Gensini积分<60分,n=80)、重度病变组(Gensini积分≥60分,n=28)。比较对照组、轻中度病变及重度病变组FAR、血小板参数,Spearman相关系数分析FAR、各血小板参数与冠脉病变程度的相关性,采用受试者工作特征(ROC)曲线下面积(AUC)检验FAR、各血小板参数联合评价冠脉病变程度的价值。结果:轻中度病变及重度病变组FAR、MPV、PDW均高于对照组,且重度病变组高于轻中度病变组,差异均有统计学意义(P<0.05);轻中度病变及重度病变组PLT低于对照组,重度病变组低于轻中度病变组,差异均有统计学意义(P<0.05);Spearman相关系数分析显示,FAR、MPV、PDW与冠脉病变程度正相关(r=0.473、0.451、0.468,P<0.05),PLT与冠脉病变程度负相关(r=-0.397,P<0.05);根据ROC曲线下AUC预测价值,FAR、各血小板参数联合评估冠脉病变程度的AUC为0.938(95%CI:0.881~0.994)(P<0.05)。结论:FAR、各血小板参数与冠脉病变程度显著相关,且各指标联合检测预测CHD冠脉病变效能良好,可将这些指标综合分析作为临床诊断冠脉疾病和冠脉病变程度的首选生物标志物。
Abstract：Objective: To explore the correlation of fibrinogen to albumin ratio (FAR) and platelet parameters with degree of coronary artery lesion. Methods: The clinical data of 154 patients who received coronary angiography in the hospital were retrospectively analyzed from January 2021 to August 2024. The enrolled patients were assigned into coronary heart disease (CHD) group (n=108) and reference group (n=46) by coronary angiography results. By means of the evaluation results of Gensini score system, the patients in the CHD group were classified into mild-to-moderate lesion group (80 cases, Gensini score<60 points) and severe lesion group (28 cases, Gensini score≥60 points). The FAR and platelet parameters were compared among the reference group, mild-to-moderate lesion group and severe lesion group. The correlation of FAR and various platelet parameters with coronary artery lesion degree was explored by Spearman correlation coefficient. The area under the receiver operating characteristic (ROC) curve (AUC) was used to test the value of combination of FAR and platelet parameters in assessing the degree of coronary artery lesion. Results: The FAR, MPV and PDW in the mild-to-moderate lesion group and the severe lesion group were higher than those in the reference group, and the above indicators in the severe lesion group were higher compared with those in the mild-to-moderate lesion group (P<0.05). PLT was lower in the mild-to-moderate lesion group and the severe lesion group than that in the reference group, and was also lower in the severe lesion group compared to the mild-to-moderate lesion group (P<0.05). Spearman correlation coefficient analysis revealed that FAR, MPV and PDW were positively correlated with coronary artery lesion degree (r=0.473, 0.451, 0.468, P<0.05), and PLT was negatively associated with the degree of coronary artery lesion (r=-0.397, P<0.05). According to the AUC predictive value under the ROC curve, the AUC of FAR combined with platelet parameters was 0.938 (95%CI: 0.881~0.994) in assessing the degree of coronary artery lesion (P<0.05). Conclusion: FAR and platelet parameters are significantly correlated with the degree of coronary artery lesion, and the combined detection of various indicators is effective in predicting coronary artery lesion in CHD. These indicators can be comprehensively analyzed as the preferred biomarkers for clinical diagnosis of coronary artery disease and coronary artery lesion degree.
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2025, Vol. 31 
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