Abstract：Objective: To investigate the correlation of serum IL-10 and serum sPD-1 with the severity and prognosis of psoriasis. Methods: Totally 150 psoriasis patients who received treatment in Chengde Central Hospital from March 2021 to February 2024 were selected as the research subjects and included in the study group. According to the scoring results of Psoriasis Skin Area and Severity Index (PASI), the study group was further divided into a mild group (81 cases) and a moderate to severe group (69 cases). Another 75 healthy individuals who underwent physical examinations during the same period were selected as the control group. Serum IL-10 and sPD-1 levels were compared between the study group and the control group; PASI scores, serum IL-10 level, and sPD-1 level were compared between the mild and moderate to severe groups. The correlation of serum IL-10 and sPD-1 levels with the severity of psoriasis was analyzed. PASI scores, serum IL-10 level, and sPD-1 level of psoriasis patients were compared before and after treatment. Results: Compared with the control group, the study group had lower serum IL-10 level and higher serum sPD-1 level, with significant statistical difference (P<0.05). The PASI score and serum sPD-1 level in the mild group were lower, while serum IL-10 level was higher, than those in the moderate to severe group, and the differences were statistically significant (P<0.05). The severity of psoriasis is negatively correlated with serum IL-10 level and positively correlated with serum sPD-1 levels (P<0.05). Before treatment, after 2 weeks treatment, and after 4 weeks treatment, PASI score and serum sPD-1 level of psoriasis patients decreased sequentially, while serum IL-10 level increased sequentially, with significant statistical differences (P<0.05). Conclusion: Serum IL-10 level is negatively correlated with the severity and prognosis of psoriasis patients, while serum sPD-1 level is positively correlated. Both serum IL-10 and sPD-1 levels can serve as important reference indicators for the clinical diagnosis and treatment of psoriasis.
高悦, 樊磊强, 陈慧君. 银屑病患者血清IL-10 血清sPD-1与病情严重程度预后转归的相关性[J]. 河北医学, 2025, 31(9): 1543-1547.
GAO Yue, FAN Leiqiang. The Correlation of Serum IL-10 and Serum sPD-1 with the Severity and Prognosis of Psoriasis. HeBei Med, 2025, 31(9): 1543-1547.
2025, Vol. 31 
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