Abstract：Objective: To investigate the value of quantitative multislice spiral CT (MSCT) parameters combined with serum tissue-type inhibitor of metalloproteinase-1 (TIMP-1) and hypoxia-inducible factor-1α (HIF-1α) in the diagnosis and management of chronic obstructive pulmonary disease (COPD). Methods: A total of 83 suspected COPD patients diagnosed in our hospital from September 2021 to September 2023 were selected. After pathological examination, as well as lung function and chest CT, 52 patients were confirmed to have COPD and were classified as the observation group, while the remaining 31 patients were classified as the control group. All underwent MSCT quantitative examination. The quantitative parameters of MSCT were calculated, including the ratio of wall thickness to diameter (TDR), lumen area (Ai), the ratio of wall thickness to body surface area (T/BSA), and the percentage of bronchial wall area (WA%). The levels of TIMP-1 and HIF-1α were detected. Multivariate Logistic regression analysis was conducted to analyze the independent risk factors influencing the occurrence of COPD. The correlation between the quantitative parameters of MSCT and TIMP-1 and HIF-1α was analyzed. The correlation between TIMP-1, HIF-1α and different severity levels of the disease were analyzed. Results:Compared with the control group, the parameter levels of TIMP-1, HIF-1α, TDR, T/BSA and WA% in the observation group increased, while the Ai level decreased (P<0.05). The parameter levels of TDR, T/BSA and WA% in severe patients were higher than those in mild and moderate patients, while the Ai level was lower than that in mild and moderate patients (P<0.05). Compared with mild and moderate patients, the levels of TIMP-1 and HIF-1α in severe patients were both increased (P<0.05). The results of multivariate Logistic regression analysis showed that the independent risk factors influencing the occurrence of COPD included TDR, HIF-1α, T/BSA, Ai, TIMP-1, and WA%. TDR, T/BSA and WA% are positively correlated with the severity of the disease. The level of Ai was negatively correlated with the severity of the disease, while the levels of TIMP-1 and HIF-1α were positively correlated with the severity of the disease (P<0.05). TDR, T/BSA, WA% were positively correlated with TIMP-1 and HIF-1α (P<0.05). Ai was negatively correlated with the levels of TIMP-1 and HIF-1α (P<0.05). The efficacy of the combined diagnosis was significantly higher than that of the individual diagnoses of TIMP-1 and HIF-1α. Conclusion:The correlation between the quantitative parameters of multilayer spiral CT and TIMP-1, HIF-1 α levels and different disease severity, which improves the clinical application in chronic obstructive pulmonary disease.
郑国利, 刘艳, 卜春红. MSCT 定量参数与TIMP-1 HIF-1α的关系及对COPD诊断价值研究[J]. 河北医学, 2025, 31(11): 1901-1906.
ZHENG Guoli, LIU Yan, BU Chunhong. Study on the Relationship between Quantitative Parameters of MSCT and TIMP-1 HIF-1α and Their Diagnostic Value for COPD. HeBei Med, 2025, 31(11): 1901-1906.
2025, Vol. 31 
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