Abstract：Objective: To analyse the correlation between early pregnancy nuchal translucency (NT) thickness and pregnancy outcomes. Methods: A total of 77 cases with increased NT thickness were selected from pregnant women undergoing early pregnancy (11+0 to 13+6 weeks) NT ultrasound examinations from January to December 2022 at our hospital to form the study group. An age-matched control group of 80 cases with normal NT was established. Fetal structural abnormalities were assessed, and cases with increased NT underwent amniocentesis with G-banding karyotyping and/or chromosomal microarray analysis (CMA), with continuous follow-up until pregnancy completion. Results: The adverse pregnancy outcome rate in the increased NT group was 29.9%, significantly higher than the 2.5% in the normal NT group (P<0.05). An increased incidence of adverse pregnancy outcomes, foetal structural abnormalities, and chromosomal abnormalities was observed with NT thickening. This trend was particularly pronounced when NT≥4.0mm, showing statistically significant differences compared to groups with NT<4.0mm (P<0.001). Conclusion: First-trimester NT ultrasound screening serves as an effective method for early diagnosis of foetal abnormalities. Changes in NT thickness correlate closely with foetal chromosomal abnormalities. Increased NT thickness elevates the risk of foetal chromosomal and structural abnormalities, as well as the probability of adverse pregnancy outcomes.
2026, Vol. 32 
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