金属基质蛋白酶-9联合血清胆固醇在脑出血预测早期血肿扩大的临床研究

doi:10.3969/j.issn.1006-6233.2019.01.026

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Abstract Objective: To explore the feasibility of predicting early hematoma enlargement in intracerebral hemorrhage (ICH) with serum cholesterol and matrix metalloproteinase-9 (MMP-9). Methods: From November 2015 to December 2017, all ICH cases in neurosurgery department of our hospital were sorted out and classified. 162 patients who met the exclusion criteria were selected and grouped according to the results of CT examination at admission and 24 hours after admission. There were 114 patients in group A without bleeding and 48 patients in group B with rebleeding. The levels of TC, HDL-C, LDL-C and MMP-9 in serum of all patients in the two groups were compared and analyzed. Results: The serum TC content (6.02±0.53) mmol/L and LDL-C (3.43±0.88) mmol/L were significantly higher in group A than in group B (4.11±0.38) mmol/L and LDL-C. The content was (2.12±0.49) mmol/L (P<0.05); while in Group A, the serum HDL-C (1.01±0.25) mmol/L and MMP-9 (97.6±36.1) mmol/L were significant. There was a statistically significant difference between the two groups in terms of the content of HDL-C (1.98±0.41) mmol/L and MMP-9 (127.6±31.5) mmol/L in the B group (P<0.01). Conclusion: The combination of serum cholesterol (TC, HDL-C, LDL-C) and MMP-9 levels may have a predictive effect on the early hematoma volume changes in ICH, which can provide new ideas for the treatment of early ICH. It is of significance to the prognosis of this disease.

Key words： Cholesterol MMP-9 ICH Predict Hematoma

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	YUAN Yang
	GUO Zheng
	LUAN Xinping

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YUAN Yang,GUO Zheng,LUAN Xinping. Clinical Study of Metalloproteinase-9 Combined with Serum Cholesterol in Predicting Early Hematoma Expansion in Cerebral Hemorrhage[J]. HeBei Med, 2019, 25(1): 104-107.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.01.026 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I1/104

[1] Naidech AM.Diagnosis and Management of Spontaneous Intracerebral Hemorrhage[J].Contin-uum(Minneap Minn),2015,21(5):1288~1298.
[2] Takeda R,Oura T,Ooigawa H,et al. A Practical Predictive model for early hematoma expansion in spontaneous deep ganglionic intracerebral hemorrhage[J].Clin Neurol Neurosurg,2013,115:102~103.
[3] 张冠壮.脑出血转化与总胆固醇、低密度脂蛋白及高密度脂蛋白的相关性[J].实用临床医药杂志,2016,20(11):18~20.
[4] 阳清伟等,金属基质蛋白酶-9急性高血压性脑出血患者血肿扩大的相关性研究[J].中国脑血管病杂志,2013,10:312~316
[5] Broot T,Broderick J,Kothari R,et al. Early hemorrhage growth in patients with intra-cerebral hemorrhage[J].Stroke,1997,28:1.
[6] Morgenstern LB,Hemphill JC,Anderson C,et al. Guidelines for the management of spontaneous intracerebral hemorrhage:a guideline for heahhcare professionals from the American Heart As-sociation /American Stroke Association[J].Stroke,2010,41:2108.
[7] Altinta O,Duruyen H,Baran G,et al. The Relationship of Hematoma Growth to RDW in Patients with Hypertensive Intracerebral Hemorrhage[J].Turk Neurosurg,2015 Oct 22.
[8] 支燕芳,林淑琴.血脂和血清脂蛋白谱检测对脑出血与脑梗死的诊断价值[J].浙江临床医学,2015,17(1):123~125.
[9] You S,Zhong C,Xu J,et al.LDL-C/HDL-C ratio and risk of allcause mortality in patients with intracerebral hemorrhage[J].Neurol Res,2016,38(10):903~908.
[10] Noda H,Iso H,Irie F,et al.Low-density Lipoprtein cholesterol concentrations and death due to in traparenchymal hemorrhage:the Ibaraki prefectural health study[J].Circulation,2009,119:2136.
[11] 何平平,欧阳新平,唐艳艳,等.甘油三酯水平升高与动脉粥样硬化性心血管疾病的关系的研究新进展[J].中国动脉硬化杂志,2013,21(10):951~954.
[12] 卜琳琳,张卓伯,等.基质金属蛋白酶-9与脑出血的关系[J].现代生物医学进展,2016,16(4):781~784.
[13] Silva Y,Leira R,Tejada J,et al. moLecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage[J]. Stroke,2005,36:86~91.