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| Value Analysis of Brain Natriuretic Peptide Combined with D-D in Diagnosis and Treatment of Patients with Acute Exacerbation of Interstitial Lung Disease |
| LIU Li |
| Guang'an Hospital, Huaxi, Sichuan University, Sichuan Guang'an638500, China |
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Abstract Objective: To study and analyze the diagnostic value of brain natriuretic peptide combined with D- two (D-D) in patients with acute exacerbation of interstitial lung disease. Methods: From June 2015 to August 2016, 50 patients with acute exacerbation of interstitial lung disease were treated in our hospital. The death group was divided into 28 cases in the death group and 22 in the survival group. Brain natriuretic peptide and D-D levels were detected in all patients. Baseline data, brain natriuretic peptide and D-D levels, clinical symptoms and signs, serum IL-6 and C reactive protein levels were compared between the two groups. Results: There was no significant difference in the sex, weight, age and past medical history between the death group and the survival group (P > 0.05). The brain natriuretic peptide and D-D level in the death group were (744.6 + 248.2) ng/ml and (4245.5 + 1584.2) pg/ml respectively, which were all higher than those of the survival group (32.5 + 10.3) ng/ml and (425.3 + 242.5) pg/ml, all of which were significantly different (P < 0.05). Death group of patients with dyspnea, hemoptysis, fever, chest pain, syncope, lower extremity edema and lung wet incidence rale were 82.14% (23/28), 28.57% (8/28), 67.86% (19/28), 42.86% (12/28), 39.29% (11/28), 50.00% (14/28), 100.00% (28/28), were higher than in survival group 50.00% (11/22), 4.55% (1/22), 18.18% (4/22), 13.64% (3/22), 13.64% (3/22), 18.18% (4/22), 54.55% (12/28), all had significant differences (all P < 0.05). Death patients serum IL - 6 and C - reactive protein levels respectively was (13.1±2.6)ng/L, (137.8±11.6) mg/L, were higher than in survival group (6.5±3.5 )ng/L, (9.6±6.1) mg/L, all have significant differences (all P < 0.05). Conclusions: In clinical work, the brain natriuretic peptide and D-D level can be used to predict the acute exacerbation of interstitial lung disease, and can be known as an effective indicator of the prognosis of patients with acute exacerbation of interstitial lung disease.
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2018, Vol. 24 
