HIF-1α Glut-1表达与乳腺癌分化程度及分子亚型的关系

doi:10.3969/j.issn.1006-6233.2018.03.001

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Abstract Objective: To investigate the relationship between the expression of -1 - alpha (HIF-1-α), glucose transporter 1 (Glut-1) and the degree of differentiation and molecular subtypes of breast cancer. Methods: Immunohistochemical method was used to detect the expression of HIF-1α and Glut-1 in 102 cases of breast cancer and 60 cases of adjacent normal tissues. The expression rates of HIF-1α and Glut-1 in breast cancer tissues with different degree of differentiation and molecular typing were compared. Results: The positive expression rates of HIF-1α and Glut-1 protein in breast cancer tissues were 62.75% and 68.63%, respectively, which were higher than those in 11.67% normal tissues. The difference was statistically significant (P < 0.05). The positive expression rates of HIF-1α and Glut-1 protein in high differentiated breast cancer tissues were 34.78% and 40.91%, respectively, which were lower than those of moderately differentiated 60%, 68.88%, and poorly differentiated 85.29% and 88.24% (P < 0.025). The differentiation of moderately differentiated breast cancer was lower than that of poorly differentiated ones (P < 0.025). There was no significant difference in positive expression rates of HIF-1α and Glut-1 protein between Luminal A type breast caner and Luminal B type breast caner (46.67% and 51.11% vs 54.55% and 63.64%) (P > 0.017). However, the rates in Luminal A and Luminal B type breast cancer were all lower than those in tissues with over-expressed HER-2 (85.71%, 92.86%) and triple negative breast cancer (90.48% and 95.24%) (P < 0.017). There was no significant difference between HER-2 overexpression type and three yin type (P > 0.017). Conclusion: The expression of HIF-1α and Glut-1 in breast cancer patients is highly positive, and the positive expression of HIF-1 alpha and Glut-1 in different degree of differentiation and molecular subtype of breast cancer is different.

Key words： Hypoxia inducible factor-1α Glucose transporter 1 Breast cancer Molecular classification Differentiation degree

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.03.001 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I3/353

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