miR-381在食管癌组织中的表达及临床意义

doi:10.3969/j.issn.1006-6233.2018.03.003

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Abstract Objective: To investigate the expression of miR-381 in tissues of esophageal cancer and its clinical significance. Methods: 108 cases of esophageal cancer admitted to our hospital were selected as the research object, and the QRT-PCR method was used to detect the expression of miR-381 in postoperative cancer tissues and adjacent normal tissues.Analyzed the relationship between the expression of miR-381 and the clinicopathological features of esophageal cancer patients. Results: The expression of miR-381 in esophageal cancer tissues was significantly lower than that in adjacent normal tissues (0.47 ± 0.22 vs 1.02 ± 0.97),and the difference was statistically significant (P <0.05). The expression level of miR-381 in esophageal cancer was closely related to the TNM staging, differentiation degree, infiltration degree and lymph node metastasis (P <0.05), and the expression level of miR-381 in esophageal cancer tissues had no significant correlation with clinicopathological features such as gender, age, tumor diameter and tumor location (P> 0.05). Conclusions: MiR-381 in esophageal cancer is low expression, and its expression level is closely related to the occurrence and development of esophageal cancer, miR-381 may be a potential biomarker for the diagnosis of esophageal cancer and a new therapeutic target.

Key words： miR-381 Esophageal cancer QRT-PCR Pathological features

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.03.003 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I3/362

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