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| Diagnostic Values of MiR-133a and MiR-208a in Myocardial Injury after PCI in Patients with Acute Coronary Syndrome |
| ZHANG Renjie, et al |
| The First Hospital of Handan, Hebei Handan 056000, China |
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Abstract Objective: To analyze the diagnostic values of miR-133a and miR-208a in myocardial injury after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods: 83 patients with ACS who underwent PCI in Handan First Hospital from June 2017 to January 2019 were divided into 41 patients with myocardial injury group and 42 patients with non-myocardial injury group according to the myocardial injury after PCI. Real-time fluorescence quantitative polymerase chain reaction (RT-PCR) was used to detect the levels of serum miR-133a and miR-208a, serum troponin I (cTnI) levels were measured by chemiluminescence immunoassay, Pearson correlation method was used to analyze the correlations between levels of serum miR-133a and miR-208a with cTnI, subject operating characteristic curve (ROC) was used to evaluate the diagnostic value of miR-133a and miR-208a in patients with myocardial injury after PCI. Results: The levels of serum cTnI and the relative expressions of miR-133a and miR-208a in myocardial injury group were significantly higher than those in non-myocardial injury group (P < 0.05); the relative expressions of miR-133a and miR-208a in serum of patients were positively correlated with the level of cTnI (r = 0.741, 0.770, P < 0.001); the areas under ROC curve (AUC) of miR-133a and miR-208a in diagnosing myocardial injury after PCI in ACS patients were 0.809 (95%CI was 0.825-0.961) and 0.853 (95%CI was 0.890-0.990), respectively, the diagnostic thresholds were 0.95 and 0.31, the sensitivity was 93.60% and 95.12%, the specificity was 73.80% and 83.33%, respectively. Conclusion: MiR-133a and miR-208a have good diagnostic sensitivities and specificities for myocardial injury after PCI in ACS patients. They are effective biomarkers of myocardial injury in ACS patients after PCI.
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2019, Vol. 25 
