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| Comparison of Different Doses of Sufentanil and Fentanil on Hemodynamics and Myocardial Protection During Perioperative Period of Cardiac Valve Replacement |
| ZHU Tongtong, WANG Chaoxia, QI Yue |
| Liaoyang Central Hospital, Liaoning Liaoyang 111000, China |
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Abstract Objective: To analyze the effects of different doses of sufentanil and fentanil on hemodynamics and myocardial protection during perioperative cardiac valve replacement.Methods: A total of 100 patients undergoing elective heart valve replacement in hospital from January 2018 to December 2019 were selected and randomly divided into group A (fentanyl 7μg/kg), group B (sufentanil 1μg/kg), group C (Sufentanil 1.5μg/kg), 25 patients in Group D (Sufentanil 2 μg/kg), observe the four groups of patients 5 minutes before anesthesia induction (T0), 10 minutes after anesthesia induction (T1), intubation Heart rate (HR), mean arterial pressure (MAP), cardiac troponin (cTnI) at 1 min (T2), 3 min (T3) after intubation, 5 min (T4) after intubation, 10 min (T5) after intubation ), Creatine Phosphokinase Isozyme (CK-MB).Results: There were statistically significant differences in the interaction effects of HR, MAP, cTnI and CK-MB levels between the four groups, time points, and time points with the groups (P<0.05).Comparison of HR, MAP, cTnI and CK-MB levels between the four groups at T0 and T1 showed no statistically significant difference (P>0.05);T2 time point, the HR, MAP, CK-MB level comparison between the four groups, the difference Statistically significant (P <0.05); T3 time point, MAP, cTnI, CK-MB levels between the four groups, the difference was statistically significant (P <0.05); T4 time point, MAP, cTnI between the four groups Compared with CK-MB levels, the difference was statistically significant (P <0.05); at T5, the HR, MAP, cTnI, and CK-MB levels between the four groups were statistically significant (P <0.05).Conclusion: Sufentanil and fentanyl in cardiac valve replacement have similar effects on the hemodynamics of patients, but the myocardial protection of sufentanil is higher than that of fentanyl, and the effects between different doses are similar, suggesting that Reduce the amount of sufentanil used.
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2020, Vol. 26 
