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| Comparison of Different Dosages of Dexmedetomidine and Propofol in Fiberoptic Bronchoscopy Guided Endotracheal Intubation |
| CONG Lu, WANG Shanjuan |
| Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University, Shanghai 200001, China |
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Abstract Objective: To explore the application of different dosages of dexmedetomidine and propofol in tracheal intubation guided by fiberbronchoscope. Methods: From January 2017 to January 2019, 80 patients undergoing bronchofiberscope guided endotracheal intubation in our hospital were divided into four groups with 20 cases in each group according to the anesthesia dosage of dexmedetomidine and propofol. The hemodynamic indexes MAP, HR and SpO2 at T0, T1, T2, T3, T4 and T5 were compared between the two groups. Results: Repeated measurement analysis of variance showed that HR, SpO2, MAP time factors, time factors and group interaction were statistically significant (P<0.05); further comparison between the two groups showed that SpO2 value at T2, T3, T4 time was significantly lower than that at to time, map value at T2, T3, T4 time was significantly higher than that at to time; the fluctuation of HR, SpO2, MAP with time in group A was smaller than that in group B, group B was smaller than that in group C, and group C was smaller than that in group D, the difference was statistically significant (P<0.05). The success rate of intubation in group D (70.00%) was significantly lower than that in group A (95.00%) and group C (95.00%), the time of apnea in group C was significantly higher than that in group A, group B, group D, the time of intubation in group C was significantly lower than that in group A, group B, group D (P<0.05). The incidence of respiratory inhibition and bradycardia in group C was significantly higher than that in the other three groups, and the incidence of cough in group D was significantly higher than that in the other three groups (P<0.05). Conclusion: Different dosages of dexmedetomidine and different doses of propofol are safe and effective in fiberoptic bronchoscopy guided endotracheal intubation, and 1.0 μ g / kg dexmedetomidine and 0.8 mg / kg propofol are suitable for stabilizing hemodynamics, improving the success rate of intubation and reducing adverse reactions.
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2020, Vol. 26 
