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| Correlation of Plasma Hcy, MMP-9 and ApoE Levels with Brain SWI Imaging Features in Patients with Stroke |
| DU Yuping, CHEN Yang |
| 904 Hospital of Joint Logistics Support Force,Jiangsu Wuxi 214000,China |
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Abstract Objective: To explore the correlation between plasma homocysteine (Hcy),serum matrix metalloproteinase-9 (MMP-9) and apolipoprotein (ApoE) levels and head susceptibility-weighted imaging (SWI) features in stroke patients.Methods: 96 stroke patients admitted to the hospital between January 2017 and January 2019 were selected as the observation group.Meanwhile,44 healthy people were selected as the control group.Head SWI examination and plasma Hcy,MMP-9 and ApoE detection were performed.The number and location of bleeding displayed by head SWI images,Hcy,MMP-9 and ApoE levels were compared between the two groups.Results: The SWI-MRI examination results showed that the sensitivity of SWI sequence was significantly higher than that of DWI,T1WI and T2WI (P<0.05).Plasma Hcy,ApoE and MMP-9 levels were significantly higher in observation group than control group (P<0.05),and significantly higher in patients with large infarction than those with middle and small infarction (P<0.05).In the observation group,plasma Hcy,MMP-9 and ApoE levels were positively correlated with the number and volume of stroke lesions and the number of cerebral cortical lesions (P<0.05).The expression level of ApoE was positively correlated with the number of deep white matter lesions (P<0.05).Logistics regression analysis showed that plasma Hcy,MMP-9 and ApoE levels were significantly correlated with the diagnostic results of SWI (P<0.05).Conclusion: The expression levels of Hcy,MMP-9 and ApoE are positively correlated with the number and volume of stroke lesions and cortical lesions displayed by SWI.The expression level of ApoE is positively correlated with white matter lesions.Hcy,MMP-9 and ApoE levels are independent risk factors of stroke development.
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2020, Vol. 26 
