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| Analysis of Clinical Characteristics and Factors Influencing the Long-Term Prognosis of Patients with Premature Coronary Artery Disease by Gender After Percutaneous Coronary Intervention |
| HUO Mingyan, ZHANG Na, LIU Yahuan, et al |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the clinical characteristics of patients with premature coronary artery disease (PCAD) by gender after percutaneous coronary intervention (PCI), to analyze factors influencing long-term prognosis, and to provide guidance for the treatment of patients. Methods: Totally 150 patients admitted to the Affiliated Hospital of Chengde Medical University from February 2018 to February 2020 who were diagnosed with coronary heart disease and underwent percutaneous coronary intervention were selected as research subjects and divided into male and female groups. The clinical data, interventional treatment data and follow-up of all patients were recorded, the clinical characteristics of premature coronary artery disease (PCAD) were analyzed, and the influencing factors of long-term prognosis were further explored. Results: In the male group, the age of onset was younger (P＜0.01), the proportion of smoking was higher (P＜0.05), the BMI index was higher, and the proportion of ST-segment elevation myocardial infarction (P＜0.05), the glomerular filtration rate (P＜0.01) ), left ventricular end-diastolic diameter (P<0.01), and hyperlipidemia (P<0.05) were all high, while the incidence of hypertension (P<0.05) and diabetes (P<0.05) was low, and the incidence of previous stroke was high. (P<0.05), which was statistically significant after statistical analysis. However, there was no statistical difference in the left ventricular ejection fraction and GRACE score between the two groups (P>0.05); the incidence of adverse events between the two groups ( including MACCE, death, myocardial infarction, revascularization, and stroke) showed no significant difference (P>0.05), but the bleeding rate in the female group was significantly higher than that in the male group. Bleeding differences are mainly manifested in the distinction between BARC levels 1-2. Statistical analysis showed statistical difference (P<0.05). Conclusion: The clinical characteristics of patients with premature coronary artery disease of different genders after percutaneous coronary intervention are different. Individualized treatment regimens should be followed for patients of different genders, and patients should be encouraged to develop a good life style and reduce their stress. Metabolic abnormalities are expected to reduce the incidence of premature coronary artery disease. Secondly, women and myocardial infarction are the influencing factors of postoperative bleeding after PCI. Identifying these postoperative factors can provide certain guidance for the later treatment of patients.
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2022, Vol. 28 
