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| Relationship between LncRNA PVT1 and ABCG2 mRNA Expression and Pathological Characteristics in Breast Cancer Tissues and Analysis of KM Curve |
| XU Liang, et al |
| Chizhou People's Hospital, Anhui Chizhou 247000, China |
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Abstract Objective: To explore the relationship between long-chain non-coding RNA plasmacytoma ectopic variant gene 1 (LncRNA PVT1), adenosine triphosphate binding transporter G2 (ABCG2) mRNA expression and pathological characteristics in breast cancer tissues, and analysis of KM curve. Methods: The case data of 80 breast cancer patients who underwent surgical treatment in our hospital between January 2017 and July 2018 were selected for retrospective study.During the operation, breast cancer tissues and adjacent tissues (2cm from the lesion) were collected to compare the expression of LncRNA PVT1 and ABCG2 mRNA in the cancer tissues and adjacent tissues.The correlation between LncRNA PVT1, ABCG2 mRNA expression and pathological characteristics in cancer tissues were analyzed.The expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues of patients with and without recurrence were compared.COX regression was used to analyze the correlation between LncRNA PVT1 and ABCG2 mRNA expressions and recurrence in cancer tissues.The disease-free survival of patients with LncRNA PVT1 and ABCG2 mRNA expression in different cancer tissues was compared. Results: The expression of LncRNA PVT1 (0.076±0.011) and ABCG2 mRNA (3.27±0.45) in cancer tissues was higher than that in adjacent tissues (0.003±0.001),(0.82±0.26)(t=59.114,42.165,P<0.05); the expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues was related to clinical stage, pathological grade, and lymph node metastasis (P<0.05); the expression of LncRNA PVT1 (0.084±0.010) and ABCG2 mRNA (3.75±0.59) in cancer tissues of relapsed patients was higher than that of non-relapsed patients (0.074±0.009),(3.13±0.47)(t=4.048,4.644,P<0.05); COX regression analysis showed that the high expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues were independent risk factors for postoperative recurrence (P<0.05); Kaplan-Meier survival analysis showed that patients with high expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues had a lower 3-year disease-free survival rate than those with low expression (P<0.05). Conclusion: The abnormally high expression of LncRNA PVT1 and ABCG2 mRNA in the cancer tissues of breast cancer patients is associated with pathological characteristics and disease-free survival, and is expected to become a new therapeutic target.
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2022, Vol. 28 
