|
|
|
| Serum Omentin-1 Changes in Osteonecrosis of the Femoral Head |
| LI GuoPeng, et al |
| Graduate School, Weifang Medical University, Shandong Weifang 261000, China |
|
|
|
|
Abstract Objective: To analyze the relationship between serum retinol-1 (Omentin-1) and non-traumatic osteonecrosis of the femoral head (NONFH).Methods: The study included 82 patients with NONFH as the patient group and 77 healthy subjects as the healthy group, and serum retinoid-1, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels were measured in both groups. Serum omentin-1 levels were compared between different etiologies, ARCO stages, and before and after collapse, and the correlation between serum omentin-1 levels and disease severity and lipid levels was analyzed to assess the value of serum omentin-1 concentrations in disease assessment using ROC curves.Results: The level of serum retinin-1 in NONFH was significantly lower than that in healthy controls (P<0.01), but there was no significant difference among patients with osteonecrosis of the femoral head (P>0.05). The level of serum retinin-1 in patients with femoral head collapse was significantly lower than that before collapse (P<0.01). The level of serum retinin-1 in patients with bilateral disease was lower than that in patients with unilateral disease, but the difference was not statistically significant (P>0.05). There was a significant difference in the level of serum retinol-1 among patients with different ARCO stages, and the level of serum retinin-1 was negatively correlated with ARCO stage, VAS score and Harris score, and negatively correlated with TC, TG and HDL. ROC curve analysis showed that the level of serum retinin-1 had a certain significance in the diagnosis of NONFH. Conclusion: The decrease of serum retinol-1 level can reflect the severity of NONFH disease and has certain significance for the clinical diagnosis and treatment of NONFH.
|
|
|
|
|
|
[1] 温家福,韦标方.激素性股骨头坏死骨髓间充质干细胞成骨分化的研究进展[J].解放军医学杂志,2020,45(11):1207-1214.
[2] Jin Y,Zhu H X,Wei B F.Reduced serum and local LncRNA MALAT1 expressions are linked with disease severity in patients with non-traumatic osteonecrosis of the femoral head[J].Technol Health Care,2021,29(3):479-488.
[3] Tang C,Liang D,Qiu Y,et al.Omentin1 induces osteoblast viability and differentiation via the TGFβ/Smad signaling pathway in osteoporosis[J].Mol Med Rep,2022,25(4):132.
[4] Yang J,Gao Y.Clinical relevance of serum omentin-1 levels as a biomarker of prognosis in patients with acute cerebral infarction[J].Brain Behav,2020,10(7):1678.
[5] Cui Q,Jo W L, Koo K H,et al.ARCO consensus on the pathogenesis of non-traumatic osteonecrosis of the femoral head[J].Korean Med Sci,2021,36(10):65.
[6] Berner H S,Lyngstadaas S P,Spahr A,et al.Adiponectin and its receptors are expressed in bone-forming cells[J].Bone,2004,35(4):842-849.
[7] Xie H,Xie P L,Luo X H,et al.Omentin-1 exerts bone-sparing effect in ovariectomized mice[J].Osteoporos Int,2012,23(4):1425-1436.
[8] 王俊江,王红建,宋晓磊,等.胸腰椎骨质疏松性骨折患者IGFBP3、IL-17、网膜素-1与骨密度、骨代谢的关系[J].分子诊断与治疗杂志,2021,13(2):183-186,190.
[9] Li Z G,Zhao D W,Xia C J,et al.Decreased synovial fluid omentin-1 concentrations reflect symptomatic severity in patients with knee osteoarthritis[J].Scand Clin Lab Invest,2012,72(8):623-628.
[10] 沈莹姗,陈哓俊,庞凤祥,等.血浆中Nesfatin-1水平变化与股骨头坏死的关系[J].中国组织工程研究,2020,24(20):3117-3121.
[11] Li Z,Liu B,Zhao D,et al.Omentin-1 prevents cartilage matrix destruction by regulating matrix metalloproteinases[J].Biomed Pharmacother,2017,92:265-269.
[12] Harmon J B,Sanders A E,Wilder R S,et al.Circulating omentin-1 and chronic painful temporomandibular disorders[J].Oral Facial Pain Headache,2016,30(3):203-209. |
|
|
|
2022, Vol. 28 
