食管癌术后并发肺部感染病原菌分布及与患者血清TNF-α IL-1β IL-8的关系

doi:10.3969/j.issn.1006-6233.2022.11.019

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Abstract Objective: To explore the distribution of pathogenic bacteria of pulmonary infection after esophageal cancer surgery and relationship with serum TNF-α, IL-1β and IL-8 of patients. Methods: 98 patients with elective thoracoscopic radical resection of esophageal cancer in the hospital between January 2020 and January 2021 were selected as the research subjects. According to postoperative pulmonary infection, the patients were divided into the infected group (32 cases) and uninfected group (66 cases). According to the CURB-65 scoring standard for the pulmonary infection degree, the patients with pulmonary infection were classified into mild group (14 cases), moderate group (11 cases) and severe group (7 cases). The distribution status of pathogenic bacteria in infected group were analyzed. Postoperative peripheral blood samples were collected from all patients, and enzyme-linked immunosorbent assay was used to detect the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-8 (IL-8). Multivariate logistic regression analysis of risk factors for postoperative pulmonary infection in patients with esophageal cancer. Spearman rank correlation analysis was applied to analyze the correlation between the above inflammatory factors and CURB-65 score. Results: 44 strains of pathogenic bacteria were isolated from 32 infected patients, including 26 strains (59.09%) of Gram-negative strains, 15 strains (34.09%) of Gram-positive strains and 3 strains (6.82%) of fungi. The proportions of patients with long-term smoking history, diabetes mellitus, tumors located in the upper/middle segment and CURB-65 score>2 in infected group were higher than those in uninfected group (P<0.05). The levels of serum TNF-α, IL-1β and IL-8 were higher in infected group than those in uninfected group (P<0.05). Serum levels of TNF-α, IL-1β and IL-8 were higher in severe group than those in mild group and moderate group, and were higher in moderate group than those in mild group (P<0.05). Multivariate Logistic regression analysis showed that long-term smoking history, diabetes mellitus, tumor located in the upper/middle segment, CURB-65 score>2 points, TNF-α≥7.44 μg/L, IL-1β≥38.21 μg/L and IL-8≥34.25 μg/L were risk factors for pulmonary infection in patients after esophageal cancer surgery (P<0.05). Serum TNF-α, IL-1β and IL-8 levels in patients with pulmonary infection were positively correlated with CURB-65 score (r=0.516, 0.589, 0.536, P<0.05). Conclusion: Serum TNF-α, IL-1β and IL-8 are highly expressed in patients with pulmonary infection after esophageal cancer surgery, and the levels of serum TNF-α, IL-1β and IL-8 are closely related to the severity of pulmonary infection. The occurrence and development of postoperative pulmonary infection in patients with esophageal cancer can be assessed clinically by detecting the levels of serum TNF-α, IL-1β and IL-8.

Key words： Radical resection of esophageal cancer Pulmonary infection Tumor necrosis factor-α Interleukin-1β Interleukin-8

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	SI Panpan
	NING Guangyao
	LU Chen
	et al

Cite this article:

SI Panpan,NING Guangyao,LU Chen, et al. Distribution of Pathogenic Bacteria of Pulmonary Infection after Esophageal Cancer Surgery and Relationship with Serum TNF-α IL-1β and IL-8 of Patients[J]. HeBei Med, 2022, 28(11): 1854-1859.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.11.019 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I11/1854

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