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| Clinical Application of Neoadjuvant Chemotherapy Combined with Breast Conserving Surgery in Patients with Early-Stage Breast Cancer |
| WANG Xiaojiao, LIAN Xiaochun, HAN Tao, et al |
| Wuhu First People's Hospital, Anhui Wuhu 241000, China |
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Abstract Objective: To investigate the clinical effect of neoadjuvant chemotherapy combined with breast conserving surgery on patients with early-stage breast cancer.Methods: A total of 90 patients with early-stage breast cancer in our hospital from January 2018 to December 2021 were selected and randomly divided into the control group of 45 cases and the observation group of 45 cases according to the random number table method. The control group was treated with breast conserving surgery only, and the observation group was treated with neoadjuvant chemotherapy combined with breast-conserving surgery. The short-term efficacy, surgical indicators and quality of life were compared between the two groups; Her-2 and Ki67, tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and Carbohydrate antigen 153 (CA153)] were different before and after treatment. Results: The overall effective rate in the observation group (91.11%) was higher than that in the control group (75.56%) (P<0.05). The observation group had less intraoperative bleeding than the control group, fewer complications than the control group, and shorter operative time than the control group (P<0.05). The KPS scores of early breast cancer patients in the 2 groups were higher after treatment than before treatment (P<0.05); the magnitude of difference before and after treatment was higher in the observation group than in the control group (P<0.05).Serum Her-2 and Ki67 levels were lower in the 2 groups than before treatment (P<0.05); the difference in the observation group was higher than that in the control group before and after treatment (P<0.05). Serum CEA, CA125 and CA153 levels were lower in the 2 groups than before treatment (P<0.05); the difference in the observation group was higher than that in the control group before and after treatment (P<0.05). Conclusion: Neoadjuvant chemotherapy combined with breast-conserving surgery is effective in the near term for patients with early-stage breast cancer, significantly improving the quality of survival, reducing Her-2 and Ki67 levels, and lowering CEA, CA125 and CA153 levels.
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2022, Vol. 28 
