宫颈环形电切术联合重组人干扰素a2b对宫颈鳞状上皮内瘤变患者疗效及对阴道微生态的影响

doi:10.3969/j.issn.1006-6233.2022.12.028

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Abstract Objective: To observe the efficacy of loop electrosurgical excision procedure (LEEP) combined with recombinant human interferon a2b gel on patients with cervical intraepithelial neoplasia (CIN) and its effects on vaginal microecology. Methods: 106 patients with CIN who were treated in the hospital between June 2019 and December 2021 were selected as the observation subjects, and they were simply divided into the observation group (n=53, LEEP+recombinant human interferon a2b gel) and the control group (n=53, LEEP) using the random number table method. Both groups were continuously treated for 4 weeks. The HPV negative conversion and vaginal microecology recovery at 3 months after treatment, and inflammatory factors and immune function before treatment and at 3 months after treatment were compared between the two groups. Results: At 3 months after treatment, the HPV negative conversion rate and effective rate were 66. 04% and 96. 23% in the observation group, which were higher than 26. 42% and 64. 15% in the control group (P<0. 05). The proportion of normal or recovered vaginal microecology (92. 45% vs 30. 38%) in the observation group was higher while the vaginal secretion pH [(4. 19±0. 52) vs (4. 46±0. 50)] and Nugent score [(2. 31±0. 45) points vs (2. 93±0. 52) points] were lower (P<0. 05) compared to the control group. The levels of INF-γ, IL-12, serum CD4⁺ and CD4⁺/CD8⁺ in the local cervical microecological environment of the two groups were higher than those before treatment, and the differences before and after treatment in the two groups were statistically significant (P<0. 05). The levels of IL-4, TNF-α and serum CD8⁺ in the local cervical microecological environment of both groups were lower than those before treatment, and the differences in the two groups before and after treatment were statistically significant (P<0. 05). Conclusion: LEEP+recombinant human interferon a2b is beneficial to increasing the negative conversion rate of HPV, reducing the inflammatory response, enhancing the immune function, and changing the prognosis of patients.

Key words： CIN LEEP Recombinant human interferon a2b gel Efficacy Vaginal microecology

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	WU Wanru
	DENG Qing
	ZHANG Cuiwen

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WU Wanru,DENG Qing,ZHANG Cuiwen. Efficacy of LEEP Combined with Recombinant Human Interferon a2b on Patients with Cervical Intraepithelial Neoplasia and Its Effects on Vaginal Microecology[J]. HeBei Med, 2022, 28(12): 2081-2085.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2022.12.028 OR http://www.hbyxzzs.cn/EN/Y2022/V28/I12/2081

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