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| Effects of Es-ketamine Combined with Propofol Anesthesia on Stress Levels Cognitive Function, and Serum BDNF and NSE Levels in Elderly Patients Undergoing Radical Mastectomy for Breast Cancer |
| PENG Changsheng, ZHOU Jianjun, HU Xuhua, et al |
| The First People's Hospital of Xiantao City, Hubei Xiantao 433000, China |
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Abstract Objective: To investigate the effects of es-ketamine combined with propofol anesthesia on stress levels, cognitive function, and serum BDNF and NSE levels in elderly patients undergoing radical mastectomy for breast cancer.Methods: Ninety elderly patients who underwent radical mastectomy for breast cancer at our hospital from May 2020 to July 2022 were selected and further divided into the observation group (45 cases, es-ketamine combined with propofol) and the control group (45 cases, propofol anesthesia) according to a random number table method. The stress levels, cognitive function, and serum BDNF and NSE levels of the two groups were compared.Results: In the observation group, cortisol and adrenaline levels at T2, T3, and T4 time points were significantly higher compared to T0 time point (P<0.05). In the control group, cortisol and adrenaline levels at T1, T2, T3, and T4 time points were significantly higher compared to T0 time point (P<0.05). The increase in cortisol and adrenaline levels at T1, T2, T3, and T4 time points in the observation group was significantly lower than that in the control group (P<0.05). Both groups showed a decrease in cognitive function scores and BDNF levels and an increase in NSE levels at 24h and 48h postoperatively, with the observation group showing better changes than the control group (P<0.05). The awakening, extubation, and orientation recovery times in the observation group were significantly shorter than those in the control group (P<0.05).Conclusion: Es-ketamine combined with propofol anesthesia in elderly patients undergoing radical mastectomy for breast cancer can reduce the body's stress response, accelerate cognitive function recovery, and improve the quality of postoperative awakening.
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2024, Vol. 30 
