不稳定型心绞痛患者血浆RANTES和MST1水平与冠状动脉斑块负荷的相关性

doi:10.3969/j.issn.1006-6233.2024.09.09

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Abstract Objective: To investigate the correlation between plasma levels of regulated upon activation, normal T-cell expressed and secreted (RANTES) and mammalian sterile 20-like kinase 1 (MST1) and coronary plaque burden in patients with unstable angina (UA).Methods: Hospitalized patients diagnosed with UA who underwent coronary angiography in the Department of Cardiology at the Affiliated Hospital of Chengde Medical College from January 2018 to January 2021 were selected. Enzyme-linked immunosorbent assay (ELISA) was used to detect plasma levels of RANTES and MST1 at admission. The extent of coronary plaque burden was quantified using the SYNTAX score and Gensini score. Patients were divided into low SYNTAX score group (≤22) and medium/high SYNTAX score group (>22). Additionally, patients were divided into low RANTES group, medium RANTES group, and high RANTES group, as well as low MST1 group, medium MST1 group, and high MST1 group based on tertiles of RANTES and MST1 levels.Results: A total of 321 cases UA patients were included in the study. Plasma levels of RANTES and MST1 were significantly higher in the medium/high SYNTAX score group compared to the low SYNTAX score group (P<0.05). The SYNTAX score was higher in the high RANTES group (18.91±6.57) than in the medium RANTES group (13.69±3.05) and the low RANTES group (10.66±6.12) (P<0.05). The SYNTAX score was higher in the high MST1 group (15.75±6.13) than in the medium MST1 group (14.43±7.51) and the low MST1 group (13.06±5.28) (P<0.05). Multivariate logistic regression analysis indicated that the highest tertiles of RANTES (OR=2.67, 95%CI 1.17~6.09, P<0.05) and MST1 (OR=5.274, 95%CI 1.769~15.722, P<0.05) were independent risk factors for medium/high SYNTAX scores. The area under the receiver operating characteristic (ROC) curve (AUC) for predicting medium/high SYNTAX scores was 0.69 (95%CI0.586~0.795, P<0.05) for RANTES,0.625 (95%CI0.553~0.696, P<0.05) for MST1, and 0.786 (95%CI0.705~0.866, P<0.001) for the combination of RANTES and MST1.Conclusion: Elevated plasma levels of RANTES and MST1 are independent risk factors for higher coronary plaque burden in patients with UA.

Key words： Unstable angina Regulated upon activation Normal T-cell expressed and secreted Mammalian sterile 20-like kinase 1

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.09.09 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I9/1462

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