罗红霉素联合糠酸莫米松鼻喷剂治疗支气管哮喘的效果及对炎症因子免疫功能的影响

doi:10.3969/j.issn.1006-6233.2024.09.029

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Abstract Objective: To explore the effects of roxithromycin combined with mometasone furoate nasal spray on serum inflammatory factors and immune function in children with bronchial asthma.Methods: A total of 120 children with bronchial asthma diagnosed in the hospital from June 2020 to June 2023 were completely randomized by random number table method into control group and experimental group, the control group was treated with mometasone furoate nasal spray, and the experimental group was treated with roxithromycin combined with mometasone furoate nasal spray for 4 weeks. Lung function, T-cell subpopulation levels, serum inflammatory factors, asthma control test (ACT) scores, quality of life, and adverse effects were compared between the two groups.Results: After treatment, peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), and FEV1/forced vital capacity (FVC) were increased in both groups, and changes in amplitude of the above indexes were greater in the experimental group (P<0.05). After treatment, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ were increased, while CD8⁺ was decreased in both groups, and changes amplitude of the above indexes was greater in experimental group (P<0.05). After treatment, levels of serum interleukin (IL)-8, IL-13, and tumor necrosis factor-α (TNF-α) were decreased, while levels of serum γ-interferon (IFN-γ), scores of ACT and quality of life were increased in both groups and changes the amplitude of the above indexes was greater in the experimental group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion: Roxithromycin combined with mometasone furoate nasal spray can improve pulmonary function, asthma control, and immune function, regulate the inflammatory response, and improve quality of life in children with bronchial asthma, which has good safety.

Key words： Bronchial asthma Mometasone furoate Roxithromycin Immune function Pulmonary function Inflammatory factor

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.09.029 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I9/1567

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