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| Diagnostic Value of Multi-Slice Spiral CT Combined with Serum ChE α-HBDH and PGRN for Pulmonary Tuberculosis Combined with Lung Cancer |
| ZHONG Linfeng, YUAN Fei, CHEN Xing, et al |
| The Third Clinical Medical College of the Three Gorges University·Gezhouba Central Hospital of Sinopharm, Hubei Yichang 443002, China |
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Abstract Objective: To explore the diagnostic value of multi-slice spiral CT combined with serum cholinesterase (ChE), α-hydroxybutyrate dehydrogenase (α-HBDH), and progranulin (PGRN) in the diagnosis of pulmonary tuberculosis combined with lung cancer. Methods: From June 2021 to June 2023, 84 patients with pulmonary tuberculosis accepted by our hospital were collected. Among them, 36 patients diagnosed with pulmonary tuberculosis combined with lung cancer through pathological examination were made the test group, and 48 patients with simple pulmonary tuberculosis were made the control group. All patients underwent multi-slice spiral CT examination. Enzyme-linked immunosorbent assay (ELISA) was applied to detect the expression levels of ChE, α-HBDH, and PGRN in serum. ROC curve was applied to analyze the diagnostic value of multi-slice spiral CT combined with serum ChE, α-HBDH, and PGRN for pulmonary tuberculosis combined with lung cancer. Results: The proportions of masses, pleural indentation sign, lobulation sign, pleural effusion, spiculation, and nodular shadow sign in the test group were higher than those in the control group (P<0.05). Compared with the control group, the serum ChE level in the test group was reduced, while α-HBDH and PGRN levels were increased (P<0.05). Compared with individual diagnosis, the combination of multi-slice spiral CT and serum ChE, α-HBDH, and PGRN had a higher AUC in the diagnosis of pulmonary tuberculosis combined with lung cancer (z=3.497, P=0.001; z=4.310, P<0.001; z=3.328, P=0.001; z=4.518, P<0.001). Conclusion: Serum ChE expression is low, and the α-HBDH and PGRN expression is high in patients with pulmonary tuberculosis combined with lung cancer. Multi-slice spiral CT combined with serum ChE, α-HBDH, and PGRN has a high diagnostic value for pulmonary tuberculosis combined with lung cancer.
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[1] 胡媛媛,丁丽麒.多元化护理干预对耐多药结核病患者负性情绪及呼吸功能锻炼依从性的影响[J].山西医药杂志,2021,50(21):3093-3095.
[2] 郝鹏菲,刘晓飞,张红,等.肺结核合并非小细胞肺癌患者临床特征分析:一项单中心临床研究[J].科学技术与工程,2022,22(35):15554-15564.
[3] 陈媛慧,张华.多层螺旋CT扫描在肺结核与肺癌空洞鉴别诊断中的应用[J].当代医学,2020,26(23):173-174.
[4] Ran H,Ma J,Cai L,et al Serum cholinesterase may independently predict prognosis in non-small-cell lung cancer[J].BMC Cancer,2022,22(1):93-100.
[5] Yuan ZM,Wang LH,Chen C.Prognostic value of serum α-HBDH levels in patients with lung cancer[J].World Surg Oncol,2023,21(1):78-85.
[6] Chen S,Bie M,Wang X,et al.PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling[J].Genes Dis,2021,9(6):1650-1661.
[7] 中华人民共和国国家卫生和计划生育委员会.肺结核诊断[J].传染病信息,2017,30(6):1-12.
[8] 朱方,赵慧慧,蒋文,等.卡瑞利珠单抗治疗晚期非小细胞肺癌致内分泌系统不良反应临床观察[J].安徽医药,2023,27(9):1904-1908.
[9] 李小辉,魏思昂,陈树嘉,等.中国城乡居民饮食结构改变与心血管疾病相关性分析[J].中国食物与营养,2023,29(2):81-84.
[10] Seo M,Yamada T,Tamaki S,et al.Prognostic significance of serum cholinesterase level in patients with acute decompensated heart failure with preserved ejection fraction:insights from the PURSUIT-HFpEF registry[J].Am Heart Assoc,2020,9(1):14100-14110.
[11] Friedman JR,Richbart SD,Merritt JC,et al.Acetylcholine signaling system in progression of lung cancers[J].Pharmacol Ther,2019,194(1):222-254.
[12] Zhan CH,Liu GJ.Diagnostic value of a combined serum α-hydroxybutyrate dehydrogenase,carcinoembryonic antigen and glycoantigen 125 test for early-stage breast cancer[J].Breast Cancer (Dove Med Press),2023,15(2):617-623.
[13] Yang Y,Yan X,Li X,et al.Long non-coding RNAs in colorectal cancer:Novel oncogenic mechanisms and promising clinical applications[J].Cancer Lett,2021,28(504):67-80.
[14] 恽骁,王高超,周含煜,等.KIFC1通过调节PI3K/AKT信号通路促进胆管癌恶性生物学行为的实验研究[J].东南大学学报:医学版,2021,40(3):277-284. |
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2024, Vol. 30 
