小剂量化疗联合术后放疗对Ⅲ期和Ⅳ期口腔癌患者预后的影响及相关因素分析

doi:10.3969/j.issn.1006-6233.2024.10.020

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Abstract Objective: To observe the impact of low-dose chemotherapy combined with postoperative radiotherapy on the prognosis of patients with stage Ⅲ-Ⅳ oral cancer and to analyze the factors affecting prognosis. Methods: A total of 90 patients with stage Ⅲ~Ⅳ oral cancer, treated at our hospital between January 2019 and May 2022, were selected and randomly divided into two groups: the control group (n=45) received postoperative radiotherapy, and the combined group (n=45) received low-dose preoperative chemotherapy combined with postoperative radiotherapy. Clinical efficacy and the 2-year recurrence rates were compared between the two groups. Based on the patients' 2-year postoperative recurrence status, they were divided into the recurrence group and the non-recurrence group, and a multivariate logistic regression analysis was conducted to identify factors influencing prognosis. Results: The disease control rate (DCR) of the combined group was significantly higher than that of the control group (P<0.05). After a 2-year follow-up, 3 patients from the combined group and 4 from the control group were lost to follow-up. Among the 83 patients who completed follow-up, 39 experienced recurrence, with an overall recurrence rate of 46.99% (39/83). The recurrence rate in the combined group was 40.48% (17/42), compared to 53.66% (22/41) in the control group, with no statistically significant difference between the two groups (P>0.05). Significant differences were observed between the recurrence and non-recurrence groups in terms of pN stage, pathological differentiation, lymph node ratio, and nerve invasion (P<0.05). Multivariate analysis showed that pN stage, lymph node ratio, and nerve invasion were influencing factors for postoperative recurrence in patients with stage Ⅲ-Ⅳ oral cancer (P<0.05). Conclusion: Low-dose chemotherapy combined with postoperative radiotherapy improves clinical efficacy in patients with stage Ⅲ-Ⅳ oral cancer, but has no significant advantage in improving prognosis. Prognosis-related factors include pN stage, lymph node ratio, and nerve invasion.

Key words： Oral cancer Chemotherapy Radiotherapy Prognosis Influencing factors

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	Articles by authors
	ZHU Ling
	DU Ruohong
	HOU Jun

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ZHU Ling,DU Ruohong,HOU Jun. Impact of Low-Dose Chemotherapy Combined with Postoperative Radiotherapy on the Prognosis of Stage Ⅲ Ⅳ Oral Cancer Patients and Analysis of Related Factors[J]. HeBei Med, 2024, 30(10): 1690-1694.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.10.020 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I10/1690

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