|
|
|
| Value of Neutrophil Combined with Coagulation Parameters on Predicting Lower Extremity Deep Venous Thrombosis after Craniocerebral Trauma Surgery |
| TANG Tingjun, PENG Gutao, XIAO Wenfeng, et al |
| Fuling Hospital, Chongqing University, Chongqing 408000, China |
|
|
|
|
Abstract Objective: To explore and analyze the association between changes of neutrophil (NE) and coagulation parameters and lower extremity deep venous thrombosis (DVT) in patients after craniocerebral trauma surgery.Methods: A total of 105 patients with craniocerebral trauma in the hospital were enrolled from April 2021 to April 2024. The changes of NE, four coagulation indexes and D-dimer (D-D) were measured after surgery. Logistic regression analysis was used to analyze the related factors affecting the occurrence of lower extremity DVT, and receiver operating characteristic curve (ROC) was drawn to evaluate the predictive efficiency of NE and coagulation parameters on lower extremity DVT.Results: The thrombin time (TT), prothrombin time (PT) and activated partial prothrombin time (APTT) of lower extremity DVT patients after craniocerebral trauma surgery were significantly shorter than those of non-DVT patients (P<0.05), and the levels of NE, fibrinogen (FIB) and D-D were significantly higher (P<0.05). The proportion of tracheotomy in DVT patients was higher than that in non-DVT patients, and the surgical time was longer than that in non-DVT patients (P<0.05). Logistic regression analysis suggested that tracheotomy, surgical time, NE, PT, FIB and D-D were the risk factors affecting postoperative lower extremity DVT (P<0.05). ROC curve indicated that the AUCs of NE, PT, FIB and D-D in evaluating lower extremity DVT were 0.787, 0.769, 0.707 and 0.779 respectively. The AUC of the combination of the four indexes in assessing lower extremity DVT was 0.958, and the sensitivity and specificity under the maximum Youden index were 0.962 and 0.899 respectively.Conclusion: The abnormal changes of coagulation parameters such as NE, PT, FIB and D-D in patients after craniocerebral trauma surgery are related to the risk of lower extremity DVT, and the combination of NE, PT, FIB and D-D has high predictive value on lower extremity DVT.
|
|
|
|
|
|
[1] Scarboro M,McQuillan KA.Traumatic brain injury update[J].AACN Adv Crit Care,2021,32(1):29-50.
[2] Robinson CP.Moderate and severe traumatic brain injury[J].Continuum (Minneap Minn),2021,27(5):1278-1300.
[3] Ratnasekera AM,Kim D,Seng SS,et al.Early VTE prophylaxis in severe traumatic brain injury:a propensity score weighted EAST multicenter study[J].Trauma Acute Care Surg,2023,95(1):94-104.
[4] Henke PK,Nicklas JM,Obi A.Immune cell-mediated venous thrombus resolution[J].Res Pract Thromb Haemost,2023,7(8):102268.
[5] Samuel S,Menchaca C,Gusdon AM.Timing of anticoagulation for venous thromboembolism after recent traumatic and vascular brain Injury[J].Thromb Thrombolysis,2023,55(2):289-296.
[6] Condon F,Grigorian A,Russell D,et al.Venous thromboembolism chemoprophylaxis in geriatric trauma patients with isolated severe traumatic brain injury[J].Eur Trauma Emerg Surg,2024,50(1):197-203.
[7] Constantinescu AE,Bull CJ,Goudswaard LJ,et al.A phenome-wide approach to identify causal risk factors for deep vein thrombosis[J].BMC Med Genomics,2023,16(1):284.
[8] 吴继宏,欧阳国林,陈涛,等.TT,FIB,D-D用于二次创伤骨折术后深静脉栓塞风险评估的价值[J].中国医药导报,2023,20(21):84-87.
[9] Pandey N,Kaur H,Chorawala MR,et al.Interactions between integrin α9β1 and VCAM-1 promote neutrophil hyperactivation and mediate poststroke DVT[J].Blood Adv,2024,8(9):2104-2117.
[10] Navarrete S,Solar C,Tapia R,et al.Pathophysiology of deep vein thrombosis[J].Clin Exp Med,2023,23(3):645-654.
[11] Porembskaya O,Zinserling V,Tomson V,et al.Neutrophils mediate pulmonary artery thrombosis in situ[J].Int Mol Sci,2022,23(10):5829. |
|
|
|
2024, Vol. 30 
