血清NOX4 MUC1表达水平与Ⅲ期非小细胞肺癌患者放疗疗效及随访1年总生存率的关系研究

doi:10.3969/j.issn.1006-6233.2024.12.016

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Abstract Objective: To study the relationship between expression levels of serum nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) and mucin 1 (MUC1) with radiotherapy efficacy and overall survival rate of 1-year follow-up in patients with stage Ⅲ non-small cell lung cancer (NSCLC). Methods: Totally 102 patients with stage Ⅲ NSCLC in the hospital from April 2020 to March 2023 were selected for radiotherapy intervention, and serum NOX4 and MUC1 levels were detected before radiotherapy. Another 51 healthy volunteers were selected as controls. Before radiotherapy, the inter-group levels of serum NOX4 and MUC1 were compared, and the intra-class levels of serum NOX4 and MUC1 in patients stage Ⅲ NSCLC with different clinical characteristics were assessed. According to the radiotherapy effect, patients with stage Ⅲ NSCLC were divided into good efficacy group and poor efficacy group, and the levels of serum NOX4 and MUC1 were compared after radiotherapy. All patients were followed up, and the 1-year overall survival rates of different patients were compared using the median levels of serum NOX4 and MUC1. Univariate and multivariate Cox regression analyses were used to analyze the influencing factors of 1-year survival rate in patients with stage Ⅲ NSCLC. Results: The levels of serum NOX4 and MUC1 in NSCLC group were significantly higher than those in control group (P<0.05). There were no statistical differences in serum NOX4 and MUC1 levels among stage Ⅲ NSCLC patients with different genders, ages, body mass index (BMI) values, tumor locations, maximum tumor diameters and pathological types before radiotherapy (P>0.05). Among 102 patients with stage Ⅲ NSCLC, the radiotherapy results showed that 55 patients were in the good efficacy group and 47 patients were in the poor efficacy group. Serum levels of NOX4 and MUC1 in good efficacy group were significantly lower than those in poor efficacy group (P<0.05). The 1-year overall survival rate in high-level NOX4 group was significantly lower than that in low-level NOX4 group (P<0.05), which in high-level MUC1 group was significantly lower than that in low-level MUC1 group (P<0.05). Univariate and multivariate Cox regression analyses showed that serum NOX4 and MUC1 levels were the influencing factors of 1-year survival rate in patients with stage Ⅲ NSCLC after radiotherapy (P<0.05). Conclusion: The expression levels of serum NOX4 and MUC1 in patients with stage Ⅲ NSCLC are related to the radiotherapy efficacy and overall survival rate after one year of follow-up. The detection of serum NOX4 and MUC1 levels is helpful to evaluate the radiotherapy efficacy and early prognosis survival.

Key words： Non-small cell lung cancer Stage Ⅲ Radiotherapy Reduced nicotinamide adenine dinucleotide phosphate oxidase 4 Mucin 1

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	Articles by authors
	LU Jue
	CAI Mengjiao
	ZHANG Yingbing

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LU Jue,CAI Mengjiao,ZHANG Yingbing. Relationship between Expression Levels of Serum NOX4 and MUC1 with Radiotherapy Efficacy and 1-Year Overall Survival Rate in Patients with Stage Ⅲ Non-Small Cell Lung Cancer[J]. HeBei Med, 2024, 30(12): 2028-2033.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.12.016 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I12/2028

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