PPI指数联合NLR LMR PLR预测晚期结直肠癌患者生存预后的价值分析

doi:10.3969/j.issn.1006-6233.2025.02.026

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Abstract Objective: To investigate the value of palliative prognosis index (PPI) combined with neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and platelet-lymphocyte ratio (PLR) in predicting the survival prognosis of patients with advanced colorectal cancer (CRC). Methods: A total of 117 patients with advanced CRC from June 2019 to June 2023 were enrolled and divided into survival group (80 cases) and death group (37 cases) according to 1-year survival prognosis. Baseline data, PPI index, NLR, LMR and PLR of the two groups were compared to analyze the value of PPI index, NLR, LMR and PLR in predicting survival prognosis. Results: PPI index, NLR and PLR in death group were significantly higher than those in survival group, but LMR was significantly lower (P< 0.05). The significantly higher PPI index, NLR and PLR and lower LMR were found in patients in stage Ⅳ vs those in stage ⅢB, patients with infiltration depth T3 to T4 vs those with infiltration depth T1-T2, patients with low differentiation vs those with middle-high differentiation, and patients with distant metastasis vs those without distant metastasis(all P < 0.05). PPI index, NLR and PLR were positively correlated with clinical stage, depth of invasion and distant metastasis, but negatively correlated with differentiation degree. LMR was negatively correlated with clinical stage, depth of invasion and distant metastasis, while positively correlated with differentiation degree (P< 0.05). PPI index, NLR and PLR were independent risk factors for survival and prognosis of patients with advanced CRC, and LMR was a independent protective factor for survival and prognosis of patients with advanced CRC (P< 0.05). The AUC of PPI index, NLR, LMR and PLR in predicting survival and prognosis of patients with advanced CRC was 0.779, 0.776, 0.784 and 0.782, with the sensitivity of 70.27%, 81.08%, 75.68% and 75.68%, and the specificity of 71.25%, 66.25%, 73.75%, 72.50%, respectively. The AUC of combined prediction of survival prognosis in patients with advanced CRC was 0.936, with the sensitivity of 83.78 % and the specificity of 90.00 %, the combined prediction value was significantly higher than that of each index alone (P < 0.05). Conclusion: PPI index, NLR, LMR and PLR are closely related to clinicopathological features of patients with advanced CRC. They are independent factors influencing survival and prognosis, and their combined prediction value was is higher.

Key words： Advanced colorectal cancer Palliative prognosis index Neutrophil to lymphocyte ratio Lymphocyte to monocyte ratio Platelet to lymphocyte ratio Survival prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.02.026 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I2/320

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