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| Analysis of the Relationship Between IL-1β COX-2 and NO Levels and Postoperative Remission in Patients with Patent Foramen Ovale-Related Migraine |
| LIANG Lilong, XIONG Lingjie |
| The Second People' s Hospital of Hefei, Anhui Hefei 230011, China |
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Abstract Objective: To analyze the relationship between serum levels of interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and nitric oxide (NO) and postoperative remission in patients with patent foramen ovale (PFO)-related migraine. Methods: A total of 105 patients with PFO-related migraine who underwent interventional occlusion at our hospital from May 2020 to May 2023 were included in the study. Serum levels of IL-1β, COX-2, and NO were measured 3 days after surgery. Patients were followed up for 1 month postoperatively and divided into a remission group (n=65) and a non-remission group (n=40) based on symptom relief. The predictive value of serum IL-1β, COX-2, and NO levels for postoperative remission was evaluated using receiver operating characteristic (ROC) curve analysis. Results: Serum levels of IL-1β, COX-2, and NO were significantly higher in the non-remission group compared to the remission group (P<0.05). ROC curve analysis revealed that the combination of serum IL-1β, COX-2, and NO levels had an area under the curve (AUC) of 0.895, with a sensitivity of 85.00% and a specificity of 87.69% for predicting postoperative remission. The combined predictive efficiency was superior to that of each individual indicator (P<0.05). Conclusion: Serum levels of IL-1β, COX-2, and NO are closely associated with postoperative remission in patients with PFO-related migraine. Early postoperative measurement of these biomarkers may provide valuable predictive insights into patient outcomes.
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2025, Vol. 31 
