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| Observation on the Curative Effect of Chaihu Guizhi Decoction in the Treatment of Progressive Vitiligo |
| LIU Yuhang, JIN Qiuyue, LI Yuzhu, et al |
| The First Affiliated Hospital of Hebei University of Chinese Medicine, Hebei Shijiazhuang 050011, China |
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Abstract Objective: To observe the clinical efficacy of Chaihu Guizhi Decoction combined with 308 nm excimer laser irradiation and topical 0.1% tacrolimus ointment in the treatment of progressive vitiligo. Methods: Seventy patients with progressive vitiligo of liver depression and qi stagnation were randomly divided into a treatment group (34 cases,1 case dropped out) and a control group (33 cases,2 cases dropped out) using SPSSsoftware.Both groups received 308 nm excimer laser irradiation and topical application of 0.1% tacrolimus ointment as baseline treatment.The treatment group was administered Chaihu Guizhi Decoction orally,while the control group received compound glycyrrhizin tablets orally for 12 weeks.Clinical efficacy,traditional Chinese medicine (TCM) symptom scores,Hamilton Depression Scale (HAMD) scores,Self-Rating Anxiety Scale (SAS) scores,Dermatology Life Quality Index (DLQI) scores,and serum levels of interleukin-6 (IL-6) and interferon-γ (IFN-γ) were compared between the two groups. Results: The effective rate in the treatment group was 91.18%,significantly higher than 69.70% in the control group (P<0.05).The treatment group showed lower TCM symptom scores,HAMD scores,SAS scores,DLQI scores,and serum levels of IL-6 and IFN-γ compared to the control group (P<0.05). Conclusion: Chaihu Guizhi Decoction combined with 308 nm excimer laser irradiation and topical 0.1% tacrolimus ointment is effective in treating progressive vitiligo and significantly improves emotional symptoms.
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2025, Vol. 31 
