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| Value of Combined Detection of Urinary TIMP-2 and IGFBP7 in Predicting Early Risk of Acute Kidney Injury Complicating Severe Acute Pancreatitis |
| JIAO Nianhui, LI Xuejun, QI Huiqin, et al |
| Jinan People's Hospital, Shandong Jinan 271100, China |
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Abstract Objective: To study the value of combined detection of urinary insulin-like growth factor binding protein 7 (IGFBP7) and matrix metalloproteinase inhibitor 2 (TIMP-2) in the early risk prediction of severe acute pancreatitis (SAP) complicated with acute kidney injury (AKI). Methods: A total of 89 SAP patients admitted from January 2022 to January 2024 were retrospectively selected. According to the presence or absence of AKI, they were divided into a complicated group (complicated with AKI, 24 cases) and a single group (without AKI, 65 cases). The levels of urinary IGFBP7 and TIMP-2 in the two groups were determined by enzyme-linked immunosorbent assay (ELISA). The influencing factors of AKI in SAP patients were selected by multivariate Logistic regression analysis. The value of the bedside index for severity in acute pancreatitis (Bisap) score and the product of urinary IGFBP7 and TIMP-2 were selected by receiver operating characteristic (ROC) curve analysis. Results: The serum calcium level of the concurrent group was lower than that of the single group, and the product of urinary IGFBP7 and TIMP-2, high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), D-dimer, and Bisap score were higher, and the differences were statistically significant (P<0.05). The product of urinary IGFBP7 and TIMP-2 also increased with the increase of AKI grade in AKI patients (P<0.05). Pearson analysis showed that serum calcium level and urinary IGFBP7 and TIMP-2 product were negatively correlated in AKI patients (P<0.05), and hs-CRP, PCT, D-dimer and Bisap score were positively correlated with TIMP-2 product (P<0.05). Multivariate logistic regression analysis showed that the product of urinary IGFBP7 and TIMP-2 and Bisap score was the influencing factor of SAP complicated with AKI (P<0.05). ROC curve showed that the area under the curve (AUC) of the product of urinary IGFBP7 and TIMP-2 in the prediction of SAP complicated with AKI was higher than that of Bisap score (P<0.05). Conclusion: The significantly increased product of urinary IGFBP7 and TIMP-2 is an influencing factor of AKI in SAP patients and can assist in predicting the occurrence of AKI.
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2025, Vol. 31 
