母婴ABO血型不合引起新生儿溶血病血清学检验结果与孕妇免疫球蛋白G抗体效价的关联性分析

doi:10.3969/j.issn.1006-6233.2025.05.021

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Abstract Objective: To analyze the correlation between serologic testing results and maternal immunoglobulin G (IgG) antibody titer in hemolytic disease of newborn (HDN) induced by ABO blood group incompatibility. Methods: A total of 142 children with HDN induced by ABO blood group antigen incompatibility in the hospital were enrolled as the research objects between May 2021 and May 2024. All children underwent blood group and related serology examinations. Results: In the 142 children with HDN induced by ABO blood group antigen incompatibility, positive rates in children with groups A and B were 55.63% and 44.37%, respectively. According to serologic testing, positive rates of direct anti-human globulin test, free IgG antibody test and antibody release test were 12.68%, 48.59% and 100%, respectively. The titer distribution of IgG anti-A (B) antibody was as follows: 1∶64, 1∶128, 1∶256, 1∶592, 1∶1024, and the corresponding number of cases was as follows: 64 cases(45.07%), 37 cases(26.06%), 22 cases(15.49%), 11 cases(7.75%), 8 cases(5.63%). There were significant differences in titer distribution of IgG antibody between mild HDN group and moderate to severe HDN group (P<0.05). Conclusion: The titer of IgG antibody is correlated with the severity of HDN.

Key words： ABO blood group incompatibility Hemolytic disease of newborn Serologic test Maternal immunoglobulin G antibody titer

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	Articles by authors
	MA Yu
	YANG Jin
	SUN Renjun

Cite this article:

MA Yu,YANG Jin,SUN Renjun. Correlation between Serologic Testing Results and Maternal Immunoglobulin G antibody Titer in Hemolytic Disease of Newborn Induced by ABO Blood Group Incompatibility[J]. HeBei Med, 2025, 31(5): 824-827.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.05.021 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I5/824

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