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| Risk Factors for Recurrence and Their Predictive Value after Laparoscopic Myomectomy in Patients with Uterine Fibroids |
| DONG Xiaoli, OU Chaoyang, GENG Chen, et al |
| Jiangsu Province (Suqian) Hospital, Jiangsu Suqian 223800, China |
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Abstract Objective: To analyze the risk factors for recurrence in patients with uterine fibroids after laparoscopic myomectomy, and to explore the predictive value of risk factors on postoperative recurrence. Methods: Totally 103 patients with uterine fibroids who received laparoscopic myomectomy in the hospital were selected from February 2019 to June 2022 as the research subjects. According to the recurrence status within 2 years after surgery, the patients were classified into recurrence group (n=25) and non-recurrence group (n=78). The clinical data of all study subjects were collected, and the risk factors affecting recurrence after laparoscopic myomectomy were explored by univariate analysis and Logistic multivariate regression analysis. ROC curve was plotted to analyze the predictive value of risk factors on postoperative recurrence. Results: Univariate analysis suggested that there were statistical differences in age, menarche age, number of uterine fibroids, diameter of uterine fibroids and postoperative estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) between the recurrence group and the non-recurrence group (P<0.05). Logistic regression analysis indicated that age≥35 years old, menarche age<14 years old, number of uterine fibroids≥2, maximum fibroid diameter≥10 cm and postoperative FSH and LH were high risk factors for postoperative recurrence (P<0.05), and postoperative E2 was a protective factor (P<0.05). ROC curve showed that the area under the curve (AUC) of the combined prediction of postoperative recurrence by age, age of menarche, number of uterine fibroids and maximum fibroid diameter was 0.996, sensitivity was 100.00% and specificity was 94.87%, which was significantly better than that predicted by each factor alone (P<0.05). Conclusion: The recurrence after laparoscopic myomectomy is affected by factors such as patient age, menarche age, number of uterine fibroids, maximum fibroid diameter and hormones levels. The prediction model based on the above risk factors has good predictive value on postoperative recurrence.
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2025, Vol. 31 
