超声造影联合血清PRDX6 LTBP2对乳腺癌前哨淋巴结转移的预测价值

doi:10.3969/j.issn.1006-6233.2025.07.030

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Abstract Objective: To investigate the value of contrast-enhanced ultrasound (CEUS) combined with serum peroxide-reducing protein 6 (PRDX6) and potential transforming growth factor β binding protein 2 (LTBP2) in the prediction of sentinel lymph node metastasis (SLNM) in breast cancer (BC). Methods: A total of 116 BC patients diagnosed by pathology from January 2022 to June 2024 were selected as the study subjects, and all patients underwent CEUS examination before surgery. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum PRDX6 and LTBP2 levels, and sentinel lymph node biopsy (SLNB) and pathological examination were performed during surgery. According to the occurrence of SLNM, 116 patients with BC were divided into a metastatic group (n=46) and a non-metastatic group (n=70). The general data and serum PRDX6 and LTBP2 levels of BC patients in the metastatic group and the non-metastatic group were compared. The receiver operating characteristic (ROC) curve was used to analyze the predictive performance of CEUS, serum PRDX6 and LTBP2 alone and in combination with the detection of SLNM in BC patients. Results: There were no significant differences in age, BMI, menopause, and tumor location between the metastatic group and the non-metastatic group in BC patients (P>0.05), but there were significant differences in tumor diameter, T stage, vascular invasion, and ER status (P<0.05). The sensitivity and specificity of CEUS in the diagnosis of SLNM were 89.13% (41/46) and 88.57% (62/70), respectively, and the accuracy was 88.79% (103/116), respectively, and CEUS was highly consistent with the "gold standard" (Kappa=0.768, P<0.05). The serum levels of PRDX6 and LTBP2 in the metastatic group were significantly higher than those in the non-metastatic group (P<0.05). The results of ROC curves showed that the sensitivity and specificity of PRDX6 in the diagnosis of SLNM were 91.3% and 82.7%, respectively, and the sensitivity and specificity of LTBP2 in the diagnosis of SLNM were 71.7% and 63.1%, respectively. The sensitivity and specificity of CEUS combined with serum PRDX6 and LTBP2 in the diagnosis of SLNM were 91.3% and 82.7%, respectively, and the AUC of the combined diagnosis was significantly higher than that of CEUS, serum PRDX6 and LTBP2 alone (Z=2.548, 2.205, 1.990, P<0.05). Conclusion: CEUS combined with serum PRDX6 and LTBP2 has high predictive value for SLNM in patients with BC, which can provide an important reference for clinical diagnosis and treatment of BC.

Key words： Breast cancer Contrast-enhanced ultrasonography Sentinel lymph node metastasis Peroxiredoxin-6 Latent transforming growth factor binding protein 2

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.07.030 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I7/1215

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