宫颈癌调强放疗骨盆不同部位高低剂量区照射体积与全身血液学毒性的关系分析

doi:10.3969/j.issn.1006-6233.2025.08.013

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Abstract Objective: To analyze the relationship between high-dose and low-dose irradiation volume of different parts of the pelvis and systemic hematologic toxicities in patients undergoing intensity modulated radiotherapy (IMRT) for cervical cancer. Methods: From April 2021 to April 2024, 184 patients with cervical cancer who underwent IMRT in the hospital were selected as the research subjects. All patients underwent hematologic toxicity tests. The relationship between high-dose and low-dose irradiation volume of different parts of the pelvis and systemic hematologic toxicities was analyzed. Results: RTOG grading results showed 58 cases of grade 1~2 (negative group) and 126 cases (68.48%) of grade 3~4 (positive group). There was no statistically significant difference in age, FIGO stage, type of cancer, V5, V30, and V40 Gy between the negative group and the positive group (P>0.05). There were statistically significant differences in chemotherapy cycle, concurrent radiochemotherapy, V10, and V20 Gy between the negative group and the positive group (P<0.05). Binary logistic regression analysis results showed that concurrent radiochemotherapy, V10, and V20 Gy were independent factors influencing the evaluation results of hematologic toxicities (P<0.05). Spearman analysis results showed that there was significant correlation between V10 and V20 Gy of the iliac bone and the grade of hematological toxicity. V5, V30 and V40 Gy of the iliac bone, V5, V10, V20, V30 and V40 Gy of the pelvic floor and lumbosacral spine were not significantly correlated with hematologic toxicities (P>0.05). Conclusion: Patients undergoing IMRT for cervical cancer have a high risk of systemic hematologic toxicities. Concurrent radiochemotherapy, V10 and V20 Gy are independent factors influencing the evaluation results of hematologic toxicities in patients undergoing IMRT for cervical cancer. Moreover, V10 and V20 Gy of the iliac bone are significantly correlated with hematologic toxicities.

Key words： Cervical cancer Intensity modulated radiotherapy High-dose and low-dose zones Hematologic toxicity

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	Aynur Seyiti
	HOU Youxiang
	GAO Jie
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Aynur Seyiti,HOU Youxiang,GAO Jie, et al. Relationship between High-Dose and Low-Dose Irradiation Volume of Different Parts of the Pelvis and Systemic Hematologic Toxicities in Patients Undergoing Intensity Modulated Radiotherapy for Cervical Cancer[J]. HeBei Med, 2025, 31(8): 1309-1314.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.08.013 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I8/1309

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