血清PAR ATF5 Smad3与2型糖尿病肾病患者肾功能指标血脂水平及预后的相关性分析

doi:10.3969/j.issn.1006-6233.2025.09.017

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Abstract Objective: To explore the correlation between serum platelet albumin ratio (PAR), activating transcription factor 5 (ATF5), Smad3 with renal function indicators, blood lipid levels and prognosis in patients with type 2 diabetes nephropathy. Methods: From December 2019 to January 2022, 152 patients with type 2 diabetes nephropathy (diabetes nephropathy group) and 100 patients with T2DM (simple diabetes group) who visited our hospital were selected. The diabetes nephropathy group was assigned into good group (119 cases) and poor group (33 cases) complying with the prognosis. Pearson method was used to analyze the correlation between serum PAR, ATF5, Smad3 with renal function indexes, blood lipid levels in diabetes nephropathy group. Logistic method was performed to analyze the prognostic factors of type 2 diabetes nephropathy patients. ROC was performed to analyze the prognostic value of serum PAR, ATF5, Smad3 in patients with type 2 diabetes nephropathy. Results: The diabetes nephropathy group had conspicuously higher UACR and PAR, ATF5 and Smad3, and conspicuously lower eGFR than the simple diabetes group (P<0.05). The poor group had conspicuously higher serum PAR, ATF5, and Smad3 than good group (P<0.05). Serum PAR, ATF5, and Smad3 were positively correlated with UACR (r=0.423, 0.439, 0.431, P<0.05) and negatively correlated with eGFR (r=-0.408, -0.389, -0.396, P<0.05), respectively. Elevated serum PAR, ATF5 and Smad3 were risk factors for poor prognosis of type 2 diabetes nephropathy patients (P<0.05). The AUC of serum PAR, ATF5 and Smad3 in predicting the prognosis of type 2 diabetes nephropathy patients was 0.919, with a sensitivity of 84.85% and a specificity of 89.92%. The predictive value of the combination of the three for the prognosis of type 2 diabetes nephropathy patients was higher than that of the single prediction (Zcombination-PAR=2.562, P=0.010, Zcombination-ATF5=2.842, P=0.005, Zcombination-Smad3=2.781, P=0.005). Conclusion: The serum PAR, ATF5 and Smad3 in type 2 diabetes nephropathy patients are elevated, and the three levels are respectively related to renal function. The combined detection of the three has potential predictive value for prognosis of type 2 diabetes nephropathy patients.

Key words： Type 2 diabetes nephropathy Platelet albumin ratio Activating transcription factor 5 Smad3

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	Articles by authors
	DA Chenxing
	YANG Shujie
	XU Mengmeng

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DA Chenxing,YANG Shujie,XU Mengmeng. Analysis of the Correlation between Serum PAR ATF5 Smad3 with Renal Function Index Blood Lipid Levels and Prognosis in Patients with Type 2 Diabetes Nephropathy[J]. HeBei Med, 2025, 31(9): 1508-1514.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.09.017 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I9/1508

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