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| The Correlation of Serum IL-10 and Serum sPD-1 with the Severity and Prognosis of Psoriasis |
| GAO Yue, FAN Leiqiang |
| Chengde Central Hospital, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the correlation of serum IL-10 and serum sPD-1 with the severity and prognosis of psoriasis. Methods: Totally 150 psoriasis patients who received treatment in Chengde Central Hospital from March 2021 to February 2024 were selected as the research subjects and included in the study group. According to the scoring results of Psoriasis Skin Area and Severity Index (PASI), the study group was further divided into a mild group (81 cases) and a moderate to severe group (69 cases). Another 75 healthy individuals who underwent physical examinations during the same period were selected as the control group. Serum IL-10 and sPD-1 levels were compared between the study group and the control group; PASI scores, serum IL-10 level, and sPD-1 level were compared between the mild and moderate to severe groups. The correlation of serum IL-10 and sPD-1 levels with the severity of psoriasis was analyzed. PASI scores, serum IL-10 level, and sPD-1 level of psoriasis patients were compared before and after treatment. Results: Compared with the control group, the study group had lower serum IL-10 level and higher serum sPD-1 level, with significant statistical difference (P<0.05). The PASI score and serum sPD-1 level in the mild group were lower, while serum IL-10 level was higher, than those in the moderate to severe group, and the differences were statistically significant (P<0.05). The severity of psoriasis is negatively correlated with serum IL-10 level and positively correlated with serum sPD-1 levels (P<0.05). Before treatment, after 2 weeks treatment, and after 4 weeks treatment, PASI score and serum sPD-1 level of psoriasis patients decreased sequentially, while serum IL-10 level increased sequentially, with significant statistical differences (P<0.05). Conclusion: Serum IL-10 level is negatively correlated with the severity and prognosis of psoriasis patients, while serum sPD-1 level is positively correlated. Both serum IL-10 and sPD-1 levels can serve as important reference indicators for the clinical diagnosis and treatment of psoriasis.
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[1] Macit B,Ragi SD,Moseley I,et al.A case-control study:epigenetic age acceleration in psoriasis[J].Arch Dermatol Res,2024,316(7):340.
[2] 乔嘉熙,夏萍,陈柳青.司库奇尤单抗治疗前后银屑病局部皮损皮肤镜和反射式共聚焦显微镜特征分析[J].中华皮肤科杂志,2024,57(9):825-829.
[3] 朱小凤,林雅雯,窦越,等.HMGB1-TLR4-IL-23-IL-17A轴在寻常型银屑病患者血清中的表达水平及临床意义[J].中国免疫学杂志,2024,40(7):1479-1483.
[4] Frost B,Schmidt M,Klein B,et al.Single-cell transcriptomics reveals prominent expression of IL-14,IL-18,and IL-32 in psoriasis[J].Eur Immunol,2023,53(11):2250354.
[5] 李玲玉,范志霞,陈娇娇,等.阿维A对寻常型银屑病患者p38 MAPK信号通路及外周血IL-9、IL-10水平的影响[J].中国中西医结合皮肤性病学杂志,2022,21(6):515-518.
[6] Hofmann SR,Carlsson E,Kapplusch F,et al.Cyclic AMP response element modulator-α suppresses PD-1 expression and promotes effector CD4+ T cells in psoriasis[J].J Immunol,2021,207(1):55-64.
[7] 赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010.516-519.
[8] 张群,刘婕,谢艳飞.寻常型银屑病患者外周血Adropin和P1NP表达及临床意义[J].西部医学,2024,36(10):1517-1521.
[9] 郑易,潘丽娜,高宇.白细胞介素10在银屑病中的表达特征及影响[J].温州医科大学学报,2023,53(1):7-14
[10] 张丽,安永涛,姬静静,等.血清miR155、GATA3与寻常型银屑病患者Th1/Th2平衡、PASI评分的相关性[J].分子诊断与治疗杂志,2023,15(3):405-408. |
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2025, Vol. 31 
