|
|
|
| The Effects of Folic Acid on Homocysteine Level and Atherosclerosis in Elderly Patients with H-type Hypertension |
| DU Dan, SUN Mingyi, JI Hong |
| Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Shenyang 110032, China |
|
|
|
|
Abstract Objective: To observe the effects of folic acid on homocysteine level and atherosclerosis in elderly patients with H-type hypertension. Methods: 112 patients with H-type hypertension who were diagnosed and treated in our department from March 2015 to December 2015 were randomly divided into the control group and the observation group (56 cases). The patients in the control group were treated with routine antihypertensive therapy. The observation group was treated with folic acid on the basis of the control group. The effects of treatment on homocysteine level and atherosclerosis were compared between the two groups. Results: Compared with the control group, the total effective rate of the observation group was significantly higher than that of the control group (P <0.05). There was no significant difference in plasma Hcy, baPWV, SBP and DBP between the two groups before treatment (P> 0.05). The levels of plasma Hcy, baPWV, SBP and DBP in the two groups after treatment were significantly lower than those before treatment (P <0.05). The decrease of the indexes of the observation group was significantly higher than that of the control group (P <0.05). Conclusion: The clinical application of folic acid in the treatment of elderly patients with H-type hypertension can significantly improve the clinical treatment efficiency, improve plasma Hcy levels and atherosclerosis state, reduce blood pressure, can be applied in clinical practice.
|
|
|
|
|
|
[1] 葛久欣,刘艳,王玉倩,等.叶酸片对老年H型高血压患者骨密度及动脉粥样硬化的价值[J].世界最新医学信息文摘:电子版,2013,9(24):90~92.
[2] 唐岚,周礼清,王人佩,等.叶酸联合维生素B6对老年H型高血压患者内皮功能及预后的影响[J].中国初级卫生保健,2015,29(10):112~114.
[3] 刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(21):701~743.
[4] 唐岚,周礼清,王人佩,等.叶酸联合维生素B6对老年H型高血压患者高同型半胱氨酸血症的疗效观察[J].山西医药杂志,2016,45(4):445~447.
[5] 王东霞,吴俊.叶酸对老年H型高血压患者同型半胱氨酸水平和动脉粥样硬化的影响[J].中华老年心脑血管病杂志,2014,16(2):205~206.
[6] 刘瑶,王安伟,李俊峰,等.叶酸辅助治疗对老年H型高血压颈动脉结构和功能及基质金属蛋白酶-9的影响[J].检验医学与临床,2014,13(22):3156~3157. |
| [1] |
. [J]. 河北医学, 2017, 23(9): 1515-1518. |
|
|
|
|
2017, Vol. 23 
