Abstract：Objective: To explore the effect of metoprolol on cardiac function and QT interval dispersion in patients with third-degree atrioventricular block (AVB) treated with a DDD pacemaker. Methods: A retrospective analysis was conducted on the clinical data of patients with third-degree AVB treated with DDD pacemaker in the cardiology department of our hospital from January 2021 to January 2024. Patients who received routine treatment after surgery were included in the control group, while those who received metoprolol in addition to routine treatment were included in the observation group. Both groups were treated for 3 months. Propensity score matching with a 1∶1 nearest neighbor method was used to balance confounding factors, resulting in 63 patients per group. Cardiac function (left atrial diameter [LAD], left ventricular end-diastolic diameter [LVEDD], left ventricular mass index [LVMI]), electrocardiogram data (resting heart rate, average heart rate, QT interval dispersion), cardiac biomarkers (plasma brain natriuretic peptide [BNP], cardiac troponin I [cTnI], creatine kinase-MB[CK-MB]), and adverse reactions during treatment were compared before and 3 months after treatment. Results: After 3 months of treatment, LAD, LVEDD, LVMI, resting heart rate, average heart rate, QT interval dispersion, BNP, cTnI and CK-MB were significantly reduced compared to before treatment in both groups. The differences between the pre- and post-treatment values in the observation group were greater than those in the control group, with statistically significant differences (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment period (P>0.05). Conclusion: Metoprolol significantly improves cardiac function and cardiac biomarkers in patients with third-degree AVB treated with DDD pacemaker, optimizes QT interval dispersion, and demonstrates high safety.
杨晓, 彭海燕, 李璐娜. 美托洛尔对DDD型起搏器治疗三度房室传导阻滞患者心功能及QT间期离散度的影响[J]. 河北医学, 2025, 31(2): 339-344.
YANG Xiao, PENG Haiyan, LI Luna. Effect of Metoprolol on Cardiac Function and QT Interval Dispersion in Patients with Third-Degree Atrioventricular Block Treated with DDD Pacemaker. HeBei Med, 2025, 31(2): 339-344.
2025, Vol. 31 
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