Abstract：Objective: To investigate the pathogenic features, drug resistance and risk factors for fungal infections in patients with chronic obstructive pulmonary disease (COPD). Methods: The etiology and clinical data of COPD patients who were treated in our hospital from March 2022 to March 2024 were selected and analyzed. Results: A total of 84 strains of pathogenic bacteria were isolated from 62 patients with COPD complicated with fungal infection, including Candida albicans (41.67%), Candida tropicalis (22.62%) and Aspergillus fumigatus (14.29%). Pathogenic bacteria had good sensitivity to voriconazole and fluconazole. Age, course of disease, hypoproteinemia, hormone use time and invasive operation were independent influencing factors of fungal infection complicating COPD patients. Conclusion: The invasive strains of COPD patients with fungal infection are extensive and have certain drug resistance. The occurrence of infection is related to age, course of disease, hypoproteinemia, hormone use time and invasive operation. Paying attention to the pathogenic characteristics, drug resistance and risk factors of fungal infection, and taking timely intervention measures can help improve the quality of life of COPD patients.
孙丽莹, 江琦, 潘霓, 张兴江, 张先明. 慢性阻塞性肺疾病并发真菌感染的病原学特征耐药性和危险因素分析[J]. 河北医学, 2025, 31(6): 963-968.
SUN Liying, JIANG Qi, PAN Ni, et al. Analysis of Pathogenetic Features Drug Resistance and Risk Factors of Fungal Infections Complicating COPD. HeBei Med, 2025, 31(6): 963-968.
[1] 陈典,隆寰宇,李姝润,等.2024年GOLD慢性阻塞性肺疾病诊断、治疗、管理及预防全球策略更新要点解读[J].中国全科医学,2024,27(13):1533-1543,1567. [2] Otu A,Kosmidis C,Mathioudakis A G,et al.The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease[J].Infection,2023,51(4):813-829. [3] Guo L,Wu X,Wu X.Aspergillus infection in chronic obstructive pulmonary diseases[J].The clinical respiratory journal,2023,17(3):129-138. [4] Kahert K,Jorres R A,Behr J,et al.The Diagnosis and treatment of COPD and its comorbidities[J].Deutsches Arzteblatt international,2023,120(25):434-444. [5] Douglas A P,Stewart A G,Hallday C L,et al.Outbreaks of fungal infections in hospitals:epidemiology,detection,and management[J].Journal of fungi (Basel,Switzerland),2023,9(11):1059. [6] 王梦园,张春艳,于文文,等.2018年至2021年山东省儿童与成人临床分离真菌的构成与主要菌种的体外抗真菌药物敏感性监测[J].山东大学学报(医学版),2025,63(4):83-93. [7] Christenson S A,Smith B M,Bafadhel M,et al.Chronic obstructive pulmonary disease[J].Lancet (London,England),2022,399(10342):2227-2242. [8] Denning D W.Global incidence and mortality of severe fungal disease[J].The Lancet Infectious diseases,2024,24(7):e428-e438. [9] Niu X,Al-hatmi A M S,Vitale R G,et al.Evolutionary trends in antifungal resistance:a meta-analysis[J].Microbiology spectrum,2024,12(4):212723. [10] 白婷婷,周琴,王丹,等.2017—2023年某院真菌血流感染的菌株分布及耐药性分析[J].中国抗生素杂志,2024,49(11):1304-1308. [11] 徐丽丽,刘斌,席小青,等.老年患者肺部感染病原菌分布及耐药性分析[J].中国病原生物学杂志,2024,19(9):1075-1078,1087. [12] 栾凤武.慢性肾病住院患者细菌真菌感染临床特征分析[J].中国感染与化疗杂志,2023,23(5):667.
2025, Vol. 31 
冀公网安备13080202000786号