Changes in Pregnancy-Associated Plasma Protein-A and Placental Growth Factor Levels in Early Pregnancy and Their Predictive Value for Early-Onset Preeclampsia
LU Jiali, WANG Changhong, WAN Yang
Fuyang People's Hospital, Anhui Fuyang 236000, China
Abstract：Objective: To explore the changes in pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PLGF) levels in early pregnancy and the predictive value of the above indicators on early-onset preeclampsia. Methods: The clinical data of 138 patients with early-onset preeclampsia in the hospital from January 2019 to January 2024 and the prenatal examination reports of 100 normal pregnant women during the same period were retrospectively analyzed. Patients with early-onset preeclampsia were included in group A. According to the disease severity, patients with mild preeclampsia were enrolled as group A1 (n=79), patients with severe preeclampsia were set as group A2 (n=59). Normal pregnant women were regarded as group B. The changes of PAPP-A and PLGF levels in early pregnancy in group A and group B were observed, and receiver operating characteristic (ROC) curve was plotted to analyze the predictive efficiency of the above indicators on the occurrence of early-onset eclampsia. The levels of PAPP-A and PLGF in group A1 and group A2 at the time of diagnosis were observed, and the correlation between blood pressure at the time of diagnosis and the above two indicators was analyzed by Pearson correlation analysis. Results: Compared with group B, PAPP-A and PLGF in early pregnancy in group A were significantly lower, with statistical differences (P<0.05). ROC curve revealed that the areas under the ROC curves (AUCs) of serum PAPP-A and PLGF levels for early-onset preeclampsia prediction were 0.843 and 0.908, respectively. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) in group A1 were significantly lower than those in group A2 while serum PAPP-A and PLGF were significantly higher, with statistical differences (P<0.05). Pearson correlation analysis indicated that the SBP and DBP in pregnant women were negatively correlated with serum PAPP-A level,and PLGF level. Conclusion: The levels of serum PAPP-A and PLGF in patients with early-onset preeclampsia are decreased in early pregnancy. The two levels show high predictive efficiency on the occurrence of early-onset preeclampsia and are closely related to the blood pressure level of patients. Early detection can provide reference for the prevention of early-onset preeclampsia.
卢佳丽, 王常宏, 宛杨. 孕早期妊娠相关血浆蛋白-A 胎盘生长因子水平变化及对早发型子痫前期的预测价值[J]. 河北医学, 2025, 31(7): 1182-1185.
LU Jiali, WANG Changhong, WAN Yang. Changes in Pregnancy-Associated Plasma Protein-A and Placental Growth Factor Levels in Early Pregnancy and Their Predictive Value for Early-Onset Preeclampsia. HeBei Med, 2025, 31(7): 1182-1185.
2025, Vol. 31 
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