Effect of Endoscopy Combined with Early Somatostatin or Terlipressin Treatment for Esophagogastric Variceal Bleeding in Liver Cirrhosis on Liver and Kidney Function
WANG Xiaoxia, ZHANG Huiyue, ZUO Luo, et al
The Second Affiliated Hospital of Chengdu Medical College · China National Nuclear Corporation 416 Hospital, Sichuan Chengdu 610000, China
Abstract：Objective: To investigate the effect of endoscopy combined with early somatostatin or terlipressin treatment for esophagogastric variceal bleeding (EGVB) in liver cirrhosis on liver and kidney function. Methods: From March 2021 to March 2024, 90 patients with liver cirrhosis and EGVB were selected. Using the random number table method, they were assigned to group A (45 cases) and group B (45 cases), receiving terlipressin treatment and somatostatin treatment, respectively. Both groups underwent endoscopic ligation after 48h of treatment. The two groups were compared on hemostasis, blood routine, liver function, renal function, and adverse reactions. Results: There were no statistically significant differences in hemostasis time, early rebleeding rate, delayed rebleeding rate, differences in blood routine indices (hemoglobin, albumin, white blood cell count, red blood cell count and platelet count) before and after treatment, and overall incidence of adverse reactions between the two groups (P>0.05). After treatment, the levels of alanine aminotransferase (ALT), total bilirubin (TBIL), serum creatinine (Scr), blood urea nitrogen (BUN), aspartate aminotransferase (AST), cystatin C (Cys C) and uric acid (UA) in both groups decreased. Besides, the decreases were greater in group A (P<0.05). The creatinine clearance rate (CCR) increased in both groups, and the increase was greater in group A (P<0.05). Conclusion: Endoscopy combined with early somatostatin and endoscopy combined with terlipressin can achieve similar hemostatic effects in patients with liver cirrhosis and EGVB. However, the latter can protect the patients' liver and kidney function.
王小霞, 张慧月, 左罗, 李晓菲. 内镜联合早期生长抑素或特利加压素治疗肝硬化食管胃底静脉曲张破裂出血对肝肾功能的影响[J]. 河北医学, 2025, 31(9): 1531-1535.
WANG Xiaoxia, ZHANG Huiyue, ZUO Luo, et al. Effect of Endoscopy Combined with Early Somatostatin or Terlipressin Treatment for Esophagogastric Variceal Bleeding in Liver Cirrhosis on Liver and Kidney Function. HeBei Med, 2025, 31(9): 1531-1535.
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2025, Vol. 31 
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