Abstract：Objective: To compare the clinical efficacy and safety of cold loop resection (CSP) and endoscopic mucosal resection (EMR) for the treatment of colonic polyps. Methods: A total of 103 patients with colon polyps who visited the hospital from January 2023 to January 2024 were included in the study. They were grouped by surgical method, including 48 patients in the CSP group and 55 patients in the EMR group. The levels of inflammatory factors (IL-6, IL-1, TNF-α) in the two groups were observed, and the relevant indicators of surgery (operation time, hospital stay, completion of each operation, and number of complications) were statistically analyzed. Results: There was a statistically significant difference in the levels of two inflammatory factors, IL-6 and IL-1 (P<0.05), while there was no statistically significant difference in TNF-α (P>0.05). Regarding the surgical-related indicators, there was no statistically significant difference in the success rate of ileocecal tube insertion, the complete recovery rate of polyps, the rate of complete resection of polyps, and the rate of complete histological resection (P>0.05). There was also statistically significant difference in the duration of surgery and hospital stay, as well as the total incidence of complications (P<0.05). Conclusion: CSP has less inflammation, shorter procedure time, shorter hospitalization, fewer complications, higher probability of non-recurrence of polyps, and more advantageous safety and clinical efficacy in the treatment of colonic polyps. However, EMR has its application value for specific larger polyps, and the clinical situation should be based on the patient's reasonable choice of operation.
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2025, Vol. 31 
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