摘要目的: 探讨涎腺黏液表皮样癌(MEC)中色素框同源蛋白2(CBX2)、CBX7表达及其临床意义。方法: 收集2017年1月到2021年12月期间本院收治的94例涎腺MEC患者作为研究对象,收集癌组织和癌旁正常涎腺组织石蜡标本,免疫组化法检测涎腺MEC癌组织及癌旁组织中CBX2、CBX7蛋白的表达水平;收集患者临床病理资料及预后情况;采用Kaplan-Meier法分析癌组织中CBX2、CBX7表达与涎腺MEC患者预后的关系;采用Cox比例风险回归模型分析涎腺MEC患者预后的影响因素。结果: 涎腺MEC癌组织较癌旁组织中CBX2、CBX7阳性率均升高(60.64% vs 20.21%、56.38% vs 25.53%,P<0.05);不同发病部位、年龄、性别的涎腺MEC患者癌组织中CBX2、CBX7表达比较,差异均无统计学意义(P>0.05);与肿瘤直径<2cm、病理分级Ⅰ+Ⅱ级、无淋巴结转移、TNM分期Ⅰ+Ⅱ期的患者比较,肿瘤直径≥2cm、病理分级Ⅲ级、有淋巴结转移、TNM分期Ⅲ+Ⅳ期的患者癌组织中CBX2、CBX7阳性率升高(P<0.05);CBX2、CBX7阳性表达是涎腺MEC患者3年内死亡的危险因素(P<0.05);CBX2阳性表达患者3年生存率(38/57,66.67%)低于CBX2阴性表达患者(32/37,86.49%)(χ2=4.635,P<0.05);CBX7阳性表达患者3年生存率(35/53,66.04%)低于CBX7阴性表达患者(35/41,85.37%)(χ2=4.496,P<0.05)。结论: 涎腺MEC患者癌组织CBX2、CBX7阳性率均升高,二者的表达与患者临床病理及预后有关。
Abstract：Objective: To explore the expression and clinical significance of CBX2 and CBX7 in mucoepidermoid carcinoma (MEC) of the salivary gland. Methods: 94 patients with salivary gland MEC in our hospital from January 2017 to December 2021 were designated as subjects. Paraffin specimens of cancer tissue and normal salivary gland tissue adjacent to cancer were collected. Immunohistochemistry was used to detect CBX2 and CBX7 proteins in salivary gland MEC cancer tissues and adjacent tissues. Clinical pathological data and prognosis of patients were collected. Kaplan-Meier method was used to analyze the relationship between CBX2 and CBX7 in cancer tissues and the prognosis of salivary gland MEC. Cox proportional hazards regression model was used to analyze the factors influencing the prognosis of salivary gland MEC. Results: The positive rates of CBX2 and CBX7 in MEC cancer tissues of salivary glands were higher than those in adjacent tissues (60.64% vs 20.21%, 56.38% vs 25.53%, P<0.05). The CBX2 and CBX7 in cancer tissues of salivary gland MEC patients with different onset sites, ages, and genders showed no statistically great difference (P>0.05). For patients with tumor diameter<2 cm, pathological grade I+II, non lymph node metastasis, and TNM stage I+II, the patients with tumor diameter ≥ 2 cm, pathological grade III, lymph node metastasis, and TNM stage III+IV had higher positive rates of CBX2 and CBX7 in cancer tissue (P<0.05). The positive CBX2 and CBX7 were risk factors for mortality within 3 years in patients with salivary gland MEC (P<0.05). Patients with positive CBX2 had a lower 3-year survival rate (38/57, 66.67%) than those with negative CBX2 (32/37, 86.49%) (χ2=4.635, P<0.05). Patients with positive CBX7 had a lower 3-year survival rate (35/53, 66.04%) than those with negative CBX7 (35/41, 85.37%) (χ2=4.496, P<0.05). Conclusion: The positive rates of CBX2 and CBX7 in cancer tissues of salivary gland MEC patients are elevated, and their expression is related to the clinical pathology and prognosis.
张璇, 杨永超, 李超, 刘博, 安峰, 郝凤花. 涎腺黏液表皮样癌中CBX2 CBX7表达及其临床意义[J]. 河北医学, 2025, 31(10): 1670-1675.
ZHANG Xuan, YANG Yongchao, LI Chao, et al. Expression and Clinical Significance of CBX2 and CBX7 in Mucoepidermoid Carcinoma of Salivary Gland. HeBei Med, 2025, 31(10): 1670-1675.
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2025, Vol. 31 
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