妊娠高血压疾病血清sTWEAK Omentin水平表达及临床价值

doi:10.3969/j.issn.1006-6233.2025.10.016

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摘要 目的: 探讨妊娠高血压疾病(HDCP)患者血清可溶性肿瘤坏死因子样凋亡微弱诱导剂(sTWEAK)、网膜素(Omentin)水平及其诊断价值。方法: 选取2020年1月至2024年1月于本院入院治疗的88例HDCP患者作为观察组,依据患者病情程度,分为A组(高血压)、B组(轻度子痫前期)、C组(重度子痫前期),分别为49例、23例、16例;选择88例同期于本院进行孕检的健康孕妇作为对照组;采用酶联免疫吸附法检测血清sTWEAK、Omentin水平;Pearson分析HDCP患者血清sTWEAK、Omentin水平与血压的相关性;Logistic回归分析HDCP的相关因素;受试者工作特征曲线(ROC)分析血清sTWEAK、Omentin水平对子痫前期的临床诊断价值。结果: 观察组PLT、MPV、PDW、PagT、收缩压、舒张压水平显著高于对照组(P<0.05),血清sTWEAK、Omentin水平显著低于对照组(P<0.05);A组、B组、C组血清sTWEAK、Omentin水平依次降低(P<0.05);Pearson相关性分析结果显示,sTWEAK水平与收缩压和舒张压呈负相关关系(r=-0.497,-0.561,P<0.001),Omentin水平与收缩压和舒张压呈负相关关系(r=-0.452,-0.529,P<0.001);sTWEAK、Omentin是患者发生HDCP的保护因素(P<0.05);血清sTWEAK、Omentin诊断子痫前期的曲线下面积(AUC)为0.829、0.815,联合诊断的AUC为0.892,二者联合优于血清sTWEAK、Omentin各自单独诊断(Z二者联合-sTWEAK=2.136、Z二者联合-Omentin=2.012,均P<0.05)。结论: HDCP患者血清Omentin,sTWEAK水平明显下降,二者联合对子痫前期具有较高的诊断价值。

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关键词 ：妊娠高血压疾病, 可溶性肿瘤坏死因子样凋亡微弱诱导剂, 网膜素, 子痫前期

Abstract：Objective: To explore the serum levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Omentin in patients with hypertensive disorders complicating pregnancy (HDCP) and their diagnostic value. Methods: A total of 88 patients with HDCP who were admitted to our hospital from January 2020 to January 2024 were gathered as the observation group. According to the severity of the patient's condition, they were separated into group A (hypertension), group B (mild preeclampsia), and group C (severe preeclampsia), with 49 cases, 23 cases, and 16 cases, respectively; 88 healthy pregnant women who underwent prenatal examinations in our hospital were made the control group. Enzyme linked immunosorbent assay (ELISA) was applied to detect serum levels of sTWEAK and Omentin. Relationship between serum sTWEAK, Omentin levels and blood pressure in HDCP patients were analyzed by Pearson correlation analysis. Logistic regression was applied to analyze the influencing factors of HDCP. Receiver operating characteristic (ROC) curve was applied to analyze the clinical diagnostic value of serum sTWEAK and Omentin levels for preeclampsia. Results: The PLT, MPV, PDW, PagT, systolic blood pressure, and diastolic blood pressure in the observation group were greatly higher than those in the control group (P<0.05), while the serum levels of sTWEAK and Omentin were greatly lower than those in the control group (P<0.05). The serum levels of sTWEAK and Omentin in group A, group B, and group C decreased sequentially (P<0.05). Pearson correlation analysis showed that sTWEAK levels were negatively correlated with systolic and diastolic blood pressure (r=-0.497, -0.561, P<0.001) and Omentin levels were negatively correlated with systolic and diastolic blood pressure (r=-0.452, -0.529, P<0.001). STWEAK and Omentin were protective factors for patients with HDCP (P<0.05). The area under the curve (AUC) of serum sTWEAK and Omentin in diagnosing preeclampsia were 0.829 and 0.815, and the AUC of combined diagnosis was 0.892, the combination of the two was superior to the individual diagnosis of serum sTWEAK and Omentin (Z combination - STWEAK=2.136, Z combination - Omentin=2.012, all P<0.05). Conclusion: The serum levels of Omentin and sTWEAK in HDCP patients are greatly decreased, and the combination of the two has high diagnostic value for preeclampsia.

Key words： Hypertensive disorders complicating pregnancy Soluble tumor necrosis factor-like weak inducer of apoptosis Omentin Preeclampsia

引用本文:

华静, 胡群, 谢涛, 朱丽慈. 妊娠高血压疾病血清sTWEAK Omentin水平表达及临床价值[J]. 河北医学, 2025, 31(10): 1680-1685.
HUA Jing, HU Qun, XIE Tao, et al. Expression of Serum sTWEAK and Omentin Levels in Hypertensive Pregnancy and Their Clinical Value. HeBei Med, 2025, 31(10): 1680-1685.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.10.016 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I10/1680

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