Abstract：Objective: To investigate the relationship between thoracoscopic surgery problems and serum marker levels in elderly esophageal cancer patients. Methods: This study recruited 108 patients with esophageal cancer who underwent thoracoscopic surgery in the Department of Thoracic Surgery of our hospital from May 2021 to May 2024. These patients were categorized into two groups: a complication group and a non-complication group. The clinical data of the patients were collected, and the levels of serum markers such as carcinoembryonic antigen (CEA), squamous cell carcinoma antigen(SCC), C-reactive protein(CRP), procalcitonin(PCT), albumin(ALB), and prealbumin(PA) were detected before surgery. Results: There were no statistically significant differences between the two groups in terms of age, gender, BMI, tumor length, tumor location, and the proportion of patients with a history of alcohol consumption, diabetes, or coronary heart disease (P>0.05). However, the proportions of patients with a history of smoking, hypertension, and chronic obstructive pulmonary disease were higher in the complication group than in the no-complication group (P<0.05). Serum CRP and SCC levels were higher in the complication group, while ALB and PA were lower compared to the no-complication group (P<0.05). Multivariate logistic regression analysis revealed that SCC, CRP, ALB, and PA are all independent influencing factors for the occurrence of complications (P<0.05). The receiver operating characteristic (ROC) curve evaluation showed that the area under the curve (AUC) for predicting complications was highest for ALB and PA, at 0.781 and 0.773 respectively. The AUC for SCC and CRP were 0.645 and 0.734 respectively. The comparisons of AUCs among these indicators were as follows: ALB vs PA (Z=0.111, P=0.911), CRP vs PA (Z=0.533, P=0.581), SCC vs PA (Z=1.855, P=0.064), ALB vs CRP (Z=0.695, P=0.487), ALB vs SCC (Z=1.912, P=0.056), CRP vs SCC (Z=1.064, P=0.287). Conclusion: It suggest that serum marker levels are of great significance in predicting complications after thoracoscopic surgery in elderly patients with esophageal cancer, and can provide a powerful reference basis for clinical early intervention and improvement of patient prognosis.
李晶, 康莉, 王芳, 吕秀娜, 张靖. 血清标志物水平对老年食管癌患者胸腔镜术后并发症的预测价值分析[J]. 河北医学, 2025, 31(10): 1691-1696.
LI Jing, KANG Li, WANG Fang, et al. Predictive Value of Serum Markers in Elderly Patients with Esophageal Cancer after Thoracoscopic Surgery. HeBei Med, 2025, 31(10): 1691-1696.
[1] 许婷婷,张朋悦,冯慧,等.早期食管癌患者合并斑驳食管危险因素研究 [J].安徽医科大学学报,2024,59(4): 698-702. [2] Cameron M E,Ayzengart A L,Oduntan O,et al.Low muscle mass and radiodensity associate with impaired pulmonary function and respiratory complications in patients with esophageal cancer [J].Journal of the American College of Surgeons,2023,236(4): 677-684. [3] 中华人民共和国国家卫生健康委员会医政医管局.食管癌诊疗指南(2022年版) [J].中华消化外科杂志,2022,21(10): 1247-1268. [4] 芮向依,冯雪菲,魏楚楚,等.2007-2021年中国食管癌死亡趋势及年龄-时期-队列模型分析 [J].中华肿瘤防治杂志,2025,32(2): 70-77. [5] 张继如,方婷婷,丁怡,等.胸腹腔镜食管癌根治术老年患者术后肺部并发症与术前营养不良的关系 [J].中华麻醉学杂志,2022,42(3): 260-264. [6] White A M,Craig A J,Richie D L,et al.Nicotine is an Immunosuppressant: implications for women's health and disease [J].Journal of Neuroimmunology,2024,397(1): 578468. [7] Zhang Y,Liu C,Ma X,et al.Effect of dietary modification on gastric mucosa,gastrointestinal symptoms and nutritional status of patients with early gastric cancer after endoscopic submucosal dissection surgery: a retrospective cohort study [J].Frontiers in nutrition,2022,9(1): 741630. [8] Luo Y L,Luo S F,Luo L,et al.Effect of hydrocolloid dressing on pressure ulcer in patients with non-invasive positive pressure ventilation: a meta-analysis [J].International Wound Journal,2023,21(2):1442.
2025, Vol. 31 
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