血清趋化因子和炎症因子水平与脑出血后血肿周围水肿带及预后相关性的临床研究

doi:10.3969/j.issn.1006-6233.2025.10.022

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摘要 目的: 探讨血清趋化因子和炎症因子水平与脑出血后血肿周围水肿带及预后的相关性。方法: 纳入患者103例,依据改良Rankin量表评分将患者分为预后良好组(n=41)与预后不良组(n=62),并将预后不良组按水肿带大小进一步分组。检测患者血清中趋化因子CCL12、CCL3、CCL17以及炎症因子IL-6、TNF-α和IL-1β,分析其与水肿带体积、预后的关系。结果: 预后不良组血清趋化因子CCL12、CCL3、CCL17以及炎症因子IL-6、TNF-α和IL-1β水平显著高于预后良好组(P<0.05);在预后不良组中,水肿带较大亚组的血清炎症因子水平高于水肿带较小亚组(P<0.05)。血清趋化因子CCL12、CCL3、CCL17,以及炎症因子IL-6和IL-1β水平与血肿周围水肿带体积呈正相关(P<0.05),且还是影响水肿带体积大小的独立危险因素(P<0.05)。结论: 血清趋化因子和炎症因子水平可作为评估脑出血患者血肿周围水肿程度及预后的潜在生物标志物,其水平升高与水肿带扩大及不良预后密切相关。

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	余勇波
	林小祥
	李剑侠

关键词 ：脑出血, 趋化因子, 炎性因子, 血肿, 水肿带

Abstract：Objective: To explore the correlation between the levels of serum chemokines and inflammatory factors and the perihematomal edema zone after intracerebral hemorrhage as well as the prognosis. Methods: A total of 103 patients were split into two groups based on their scores on the modified Rankin Scale: those with a good prognosis (n=41) and those with a poor prognosis (n=62), and the poor prognosis group was further divided into subgroups according to the size of the perihematomal edema zone. The levels of serum chemokines CCL12, CCL3, CCL17 and inflammatory factors IL-6, TNF-α and IL-1β in the patients were detected, and the relationships between these factors and the volume of the edema zone as well as the prognosis were analyzed. Results: Significantly higher concentrations of serum chemokines CCL12, CCL3, CCL17, together with inflammatory mediators IL-6,TNF-α and IL-1β, were detected in the poor prognosis group than those in the good prognosis group(P<0.05). In the poor prognosis group, the levels of serum inflammatory factors in the subgroup with a larger perihematomal edema zone were higher than those in the subgroup with a smaller edema zone (P<0.05). The levels of serum chemokines CCL12, CCL3, CCL17 and inflammatory factors IL-6 and IL-1β were positively correlated with the volume of the perihematomal edema zone ( P<0.05), and they were also independent risk factors affecting the size of the volume of the edema zone (P<0.05). Conclusion: The levels of serum chemokines and inflammatory factors can serve as potential biomarkers for evaluating the degree of perihematomal edema and the prognosis in patients with intracerebral hemorrhage. An increase in their levels is closely associated with the expansion of the edema zone and a poor prognosis.

Key words： Intracerebral hemorrhage Chemokines Inflammatory factors Hematoma Perihematomal edema zone

引用本文:

余勇波, 林小祥, 李剑侠. 血清趋化因子和炎症因子水平与脑出血后血肿周围水肿带及预后相关性的临床研究[J]. 河北医学, 2025, 31(10): 1712-1717.
YU Yongbo, LIN Xiaoxiang, LI Jianxia. Clinical Research on the Correlation of Serum Chemokine and Inflammatory Factor Levels with Perihematomatous Edema Bands and Prognosis after Cerebral Hemorrhage. HeBei Med, 2025, 31(10): 1712-1717.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.10.022 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I10/1712

[1] Cui J,Ma X L,Tong J Z,et al.Observation on the clinical efficacy of external ventricular drain combined with intraventricular urokinase injection and intravenous piracetam in the treatment of intraventricular hemorrhage [J].Pakistan journal of medical sciences,2022,38(5): 1292-1297.
[2] 龙昌友,曹云太,鲍海华.高血压脑出血后血肿周围水肿相关影响因素的研究进展 [J].放射学实践,2024,39(5): 704-710.
[3] Shi H,Chen M.The brain-bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism [J].European journal of medical research,2024,29(1): 317.
[4] Wang R H,Wen W X,Jiang Z P,et al.The clinical value of neutrophil-to-lymphocyte ratio (NLR),systemic immune-inflammation index (SII),platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage [J].Frontiers in immunology,2023,14(1): 1115031.
[5] Jensen T S R,Fugleholm K,Ekstrm C T,et al.Inflammatory human leucocyte antigen genotypes are not a risk factor in chronic subdural hematoma development [J].Acta neurochirurgica,2023,165(9): 2399-2405.
[6] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国重症卒中管理指南2024[J].中华神经科杂志,2024,57(7): 698-714.
[7] 杨海军.系统免疫炎症指数与脑出血水肿严重程度及预后的相关性研究[D].兰州大学,2024.
[8] Zhang B W,Sun K H,Liu T,et al.The crosstalk between immune cells after intracerebral hemorrhage [J].Neuroscience,2024,537(1): 93-104.
[9] Trujillo-Rangel W,Acua-Vaca S,Padilla-Ponce D J,et al.Modulation of the circadian rhythm and oxidative stress as molecular targets to improve vascular dementia: a pharmacological perspective [J].International journal of molecular sciences,2024,25(8):4401.
[10] Ye J,Fan Y,Shen Y,et al.Biomimetic self-propelled asymmetric nanomotors for cascade-targeted treatment of neurological inflammation [J].Advanced science (Weinheim,Baden-Wurttemberg,Germany),2024,11(22): 2310211.
[11] Shen S,Zhong H,Zhou X,et al.Advances in traditional Chinese medicine research in diabetic kidney disease treatment [J].Pharmaceutical biology,2024,62(1): 222-232.