Abstract：Objective: To investigate the diagnostic value of serum immunoglobulin M (IgM), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels for the severity of Mycoplasma pneumoniae (MP) infection. Methods: From July 2023 to December 2024, 78 patients with MP infection were selected. Meanwhile, 27 healthy individuals were selected as the control group. The levels of IgM, IL-6, PCT and CRP in all subjects were measured. The receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic value of IgM and PCT for severe MP infection. Results: Compared with the control group, the severe group and the mild group showed higher levels of IgM, IL-6, PCT and CRP (P<0.05). Compared with the mild group, the severe group demonstrated higher levels of IgM and PCT (P<0.05). No statistically significant differences in IL-6 and CRP levels were observed between the mild group and the severe group (P>0.05). There was no statistically significant difference in data such as gender and age between the mild group and the severe group (P>0.05). According to ROC curve analysis, the areas under curves of IgM and PCT for diagnosing severe MP infection were 0.721 and 0.971, respectively. The sensitivity, specificity, and accuracy of combined diagnosis were 85.71, 98.35, and 91.03, respectively. Conclusion: IgM and PCT can serve as indicators for monitoring the condition of patients with MP infection, providing a basis for clinical judgment of condition and guiding the development of corresponding treatment plan.
孙蓓蓓, 张丽萍, 王中安. 探讨血清IgM IL-6 PCT CRP水平对肺炎支原体感染病情严重程度的诊断价值[J]. 河北医学, 2025, 31(10): 1732-1737.
SUN Beibei, et al. Diagnostic Value of Serum IgM IL-6 PCT and CRP Levels for the Severity of Mycoplasma Pneumoniae Infection. HeBei Med, 2025, 31(10): 1732-1737.
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2025, Vol. 31 
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